Ein Unternehmen der RHÖN-KLINIKUM AG

AG Jünemann/Schönburg - Heart&Brain


Jasmin El-Shazly, M. Sc.-Psych; Prof. Dr. med. Tibo Gerriets; Prof. Dr. med. Patrick Schramm; PD Dr. med. Marlene Tschernatsch-Gerriets; Marius Butz, Dipl.-Psych; Rolf Meyer, M. Sc.-Psych.

Schwerpunkte der Arbeitsgruppe

Laufende Projekte:

  • INCORE - INcreasing preoperative COgnitive REserve to prevent postoperative delirium and postoperative cognitive decline in cardiac surgical patients. A randomized controlled trial on cognitive training (RCT)
  • COSTA - Cognitive Outcome after Surgical and Transcatheter Aortic valve replacement (RCT)
  • DESTRESS-SURG - DEcreasing preoperative STRESS to prevent postoperative delirium and postoperative cognitive decline in cardiac SURGical patients. A randomized controlled trial on relaxation interventions via virtual reality and binaural beats (RCT)
  • BICAPONI - Analysis of blood BIomarkers in CArdiac surgery patients with POstoperative Neurocognitive disorders and sub-clinical brain Infarcts

Geplante Projekte:

  • RECOG - Prevention of Seizures after Cardiac Surgery to REduce Postoperative COGnitive Deficits (RCT)
  • CAVALIR - Retrospective analysis in CArdiac surgery patients of preoperative heart rate VAriability as a biomarker for postoperative deLIRium




MEDEX 2                 111.823 € William G. Kerckhoff-Stiftung
Tako-Tsubo             60.000 € Deutsche Stiftung für Herzforschung (DSHF)
COFAS                     20.000 € UKGM
ELMAR                    108.000 € Else Kröner-Fresenius-Stiftung (EKFS)
NEOCARE               75.600 Willy und Monika Pitzer-Stiftung
INCOGNITO            36.000 € William G. Kerckhoff-Stiftung + 30.300 € Deutsche Stiftung für Herzforschung (DSHF)
COFAS 1000            5.000 € William G. Kerckhoff-Stiftung


INCORE seit 2019                   45.084 € William G. Kerckhoff-Stiftung
COSTA seit 2020                     58.265 € Deutsche Stiftung für Herzforschung (DSHF)
DESTRESS seit 2022               65.106 € Deutsche Stiftung für Herzforschung (DSHF)
BICAPONI seit 2023                43.324 € William G. Kerckhoff-Stiftung

  • Prof. Dr. Georg Bachmann, Prof. Dr. Stefan Blankenberg, Prof. Dr. Andreas Böning, PD Dr. Tobias Braun, Prof. Dr. Yeong-Hoon Choi, Prof. Dr. Thorsten Döppner, PD Dr. Stefan Gerner, Prof. Dr. Bettina Hamann, Dr. Samra Hamzic, Prof. Dr. Jürgen Hennig, Prof. Dr. Till Keller, PD Dr. Won-Keun Kim, Dr. Philipp Klemm, Prof. Dr. Thomas Mengden, Prof. Dr. phil. Gebhard Sammer, Dr. Johanna Wagner-Dörr, Dipl.-Psych., Dr. Mesut Yenigün
  • Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Schramm P, Doeppner TR, Braun T, Boening A, Mengden T, Choi YH, Schoenburg M, Juenemann M. The impact of postoperative cognitive training on health-related quality of life and cognitive failures in daily living after heart valve surgery: A randomized clinical trial. Brain Behav. 2023 Mar;13(3):e2915. doi: 10.1002/brb3.2915. Epub 2023 Feb 13. PMID: 36785920; PMCID: PMC10013943.
  • Butz M, Meyer R, Gerriets T, Sammer G, Doerr JM, El-Shazly J, Doeppner TR, Choi YH, Schoenburg M, Juenemann M. Increasing preoperative cognitive reserve to prevent postoperative delirium and postoperative cognitive decline in cardiac surgical patients (INCORE): Study protocol for a randomized clinical trial on cognitive training. Front Neurol. 2022 Dec 12;13:1040733. doi: 10.3389/fneur.2022.1040733. PMID: 36578306; PMCID: PMC9791586.
  • Tschernatsch M, El Shazly J, Butz M, Lie SR, Yeniguen M, Braun T, Bachmann G, Schoenburg M, Gerriets T, Schramm P, Juenemann M. Visual Hallucinations following Coronary Artery Bypass Grafting: A Prospective Study. Medicina (Kaunas). 2022 Oct 16;58(10):1466. doi: 10.3390/medicina58101466. PMID: 36295626; PMCID: PMC9610531.
  • Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Huttner HB, Braun T, Boening A, Mengden T, Choi YH, Schoenburg M, Juenemann M. Effects of postoperative cognitive training on neurocognitive decline after heart surgery: A randomized clinical trial. Eur J Cardiothorac Surg. 2022 Apr 12:ezac251. doi: 10.1093/ejcts/ezac251. Epub ahead of print. PMID: 35415742.
  • El Shazly J, Gerriets T, Hennig J, Butz M, Kastaun S, Wiedenroth CB, Schoenburg M, Wollenschlaeger M, Bachmann G, Guth S, Juenemann M. Neuroprotective effects of dynamic bubble trap use in patients undergoing pulmonary endarterectomy: a two-arm randomized controlled trial. J Thorac Dis. 2021 Oct;13(10):5807-5817. doi: 10.21037/jtd-21-831. PMID: 34795929; PMCID: PMC8575830.
  • Hamzic S, Braun T, Butz M, Khilan H, Weber S, Yeniguen M, Gerriets T, Schramm P, Juenemann M. Transesophageal Echocardiography - Dysphagia Risk in Acute Stroke (TEDRAS): a prospective, blind, randomized and controlled clinical trial. Eur J Neurol. 2021 Jan;28(1):172-181. doi: 10.1111/ene.14516. Epub 2020 Oct 10. PMID: 32897605.
  • Tschernatsch M, Juenemann M, Alhaidar F, El Shazly J, Butz M, Meyer M, Gerriets T, Schönburg M, Schramm P. Epileptic seizure discharges in patients after open chamber cardiac surgery-a prospective prevalence pilot study using continuous electroencephalography. Intensive Care Med. 2020 Jul;46(7):1418-1424. doi: 10.1007/s00134-020-06073-8. Epub 2020 May 13. PMID: 32405742; PMCID: PMC7334279.
  • Juenemann M, Nef H, Möllmann H, Singh P, Troidl C, Schramm P, Kaps M, Gerriets T, Blaes F, Tschernatsch M. No evidence for humoral autoimmunity against cardiomyocytes, adrenergic or muscarinic receptors in patients with Tako-Tsubo cardiomyopathy. Immunobiology. 2019 Mar;224(2):220-222. doi: 10.1016/j.imbio.2018.11.005. Epub 2018 Nov 15. PMID: 30554740.
  • Kastaun S, Gerriets T, Tschernatsch M, Yeniguen M, Juenemann M. Psychosocial and psychoneuroendocrinal aspects of Takotsubo syndrome. Nat Rev Cardiol. 2016 Nov;13(11):688-694. doi: 10.1038/nrcardio.2016.108. Epub 2016 Jul 14. PMID: 27411402.
  • Kastaun S, Gerriets T, Schwarz NP, Yeniguen M, Schoenburg M, Tanislav C, Juenemann M. The Relevance of Postoperative Cognitive Decline in Daily Living: Results of a 1-Year Follow-up. J Cardiothorac Vasc Anesth. 2016 Apr;30(2):297-303. doi: 10.1053/j.jvca.2015.12.008. Epub 2015 Dec 3. PMID: 27013120.
  • Kastaun S, Gerriets T, Yeniguen M, Nef H, Moellmann H, Sammer G, Juenemann M. Locus of control and stress management strategies in women with takotsubo cardiomyopathy. Int J Cardiol. 2014 Dec 15;177(2):658-60. doi: 10.1016/j.ijcard.2014.09.173. Epub 2014 Oct 5. PMID: 25308089.
  • Kastaun S, Schwarz NP, Juenemann M, Yeniguen M, Nef HM, Moellmann H, Hamm CW, Sammer G, Hennig J, Bachmann G, Gerriets T. Cortisol awakening and stress response, personality and psychiatric profiles in patients with takotsubo cardiomyopathy. Heart. 2014 Nov;100(22):1786-92. doi: 10.1136/heartjnl-2014-305745. Epub 2014 Jul 1. PMID: 24986894.
  • Gerriets T, Schwarz N, Sammer G, Baehr J, Stolz E, Kaps M, Kloevekorn WP, Bachmann G, Schönburg M. Protecting the brain from gaseous and solid micro-emboli during coronary artery bypass grafting: a randomized controlled trial. Eur Heart J. 2010 Feb;31(3):360-8. doi: 10.1093/eurheartj/ehp178. Epub 2009 Jun 18. PMID: 19541675.