Latest Publications

Fehrendt H, Linn T, Hartmann S, Szalay G, Heiss C, Schnettler R, Lips KS.
Negative influence of a long-term high-fat diet on murine bone architecture. 
Int J Endocrinol. 2014;2014:318924. doi: 10.1155/2014/318924. Epub 2014 Feb 20.

Padmasekar M, Lingwal N, Samikannu B, Chen C, Sauer H, Linn T. 
Exendin-4 protects hypoxic islets from oxidative stress and improves islet transplantation outcome.
Endocrinology. 2013 Apr;154(4):1424-33. doi: 10.1210/en.2012-1983. Epub  2013 Mar 7. PubMed PMID: 23471218.

Blum NM, Mueller K, Lippmann D, Metges CC, Linn T, Pallauf J, Mueller AS.
Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and
hepatic antioxidant and phase II enzymes in growing rats. 

Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29. PubMed PMID: 23271678.

Jiang X, Qian T, Linn T, Cao L, Xiang G, Wang Y, Peng H, Xue P, Zhang L, Chen D, Yang X. 
Islet isolation and purification from inbred Wuzhishan miniature pigs.
Xenotransplantation. 2012 May-Jun;19(3):159-65. doi: 10.1111/j.1399-3089.2012.00702.x. PubMed PMID: 22702467.

Lingwal N, Padmasekar M, Samikannu B, Bretzel RG, Preissner KT, Linn T.
Inhibition of gelatinase B (matrix metalloprotease-9) activity reduces cellular inflammation and restores function of transplanted pancreatic islets. 
Diabetes. 2012 Aug;61(8):2045-53. doi: 10.2337/db11-1143. Epub 2012 May 14. PubMed PMID: 22586582; PubMed Central PMCID: PMC3402316.

Blum NM, Mueller K, Hirche F, Lippmann D, Most E, Pallauf J, Linn T, Mueller AS. 
Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes.
Food Funct. 2011 Nov;2(11):654-64. doi: 10.1039/c1fo10122f. Epub 2011 Sep 29. PubMed PMID: 21959850.

Chen C, Moreno R, Samikannu B, Bretzel RG, Schmitz ML, Linn T.
Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB  activity in pancreatic islets depends on oxygen availability. 
Am J Transplant. 2011 Feb;11(2):215-24. doi: 10.1111/j.1600-6143.2010.03390.x. Epub 2011 Jan 10. PubMed PMID: 21219576.

Lai Y, Brandhorst H, Hossain H, Bierhaus A, Chen C, Bretzel RG, Linn T.
Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
Islets. 2009 Jul-Aug;1(1):19-25. doi: 10.4161/isl.1.1.8530. PubMed PMID: 21084845.

Chen C, Kuehn C, Bretzel RG, Linn T. 
Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment
PLoS One. 2009 Jul 20;4(7):e6312. doi: 10.1371/journal.pone.0006312. Erratum in: PLoS One. 2009;4(11). doi: 10.1371/annotation/be980555-eeb9-4c0e-91f9-cdc1d8f2709b. PubMed PMID: 19617916; PubMed Central PMCID: PMC2708353.

Lai Y, Chen C, Linn T.
Innate immunity and heat shock response in islet transplantation. 
Clin Exp Immunol. 2009 Jul;157(1):1-8. doi: 10.1111/j.1365-2249.2009.03899.x. Epub 2009 Feb 4. Review. PubMed PMID: 19302242; PubMed Central PMCID: PMC2710586.

Drobinskaya I, Linn T, Saric T, Bretzel RG, Bohlen H, Hescheler J, Kolossov E. 
Scalable selection of hepatocyte- and hepatocyte precursor-like cells from culture of differentiating transgenically modified murine embryonic stem cells.
Stem Cells. 2008 Sep;26(9):2245-56. doi: 10.1634/stemcells.2008-0387. Epub 2008 Jun 12. PubMed PMID: 18556507.