Ausgewählte und aktuelle Publikationen

Holler JPN, Ahlbrandt J, Burkhardt E, Gruß M, Röhrig R,  Knapheide J, Hecker A, Padberg W, Weigand MA: Peridural Analgesia may affect long-term survival in patients with Colorectal cancer after Surgery (PACO-RAS-study): An analysis of a cancer registry. Annals of surgery. 2013; 257: doi: 10.1097/SLA.0b013e3182915f61  (IF: 7,492)

Zimmermann JB, Lehmann M, Hofer S, Hüsing J, Alles C, Werner J, Stiller J, Künnecke W, Luntz S, Motsch J, Weigand MA: Design of a prospective clinical study on the agreement between the Continuous Glucose Monitor, a novel device for continuous assessment of blood glucose levels, and the rapidlab(R) 1265 blood gas analyser: The CONTASSGLU study BMC Anesthesiology 2012, 12:24. doi:10.1186/1471-2253-12-24:    PDF

C. Lichtenstern, C. Koch, R. Röhrig, B. Rosengarten, M. Henrich und M.A Weigand: Nahinfrarotspektroskopie in der Sepsistherapie – Prädiktor für eine erniedrigte zentralevenöse Sauerstoffsättigung. Anaesthesist. 2012. DOI: 10.1007/s00101-012-2087-0:  PDF

V. Mann, T. Spitzner, T. Schwandner, S. T. W. Mann, M. Müller, J. Ahlbrandt, M. A. Weigand and R. Röhrig: The effect of a cervical collar on the seal pressure of the LMA Supreme™: a prospective, crossover trial. Anaesthesia (2012): Article first published online: 13 AUG 2012. DOI 10.1111/j.1365-2044.2012.07303.x  

Rörtgen D., Schaumberg A., Skorning M., Bergrath S., Beckers S.K., Coburn M., Brokmann J.C., Fischermann H., Nieveler M., Rossaint R.: Vorgehaltene Medikamente auf notarztbesetzten Rettungsmitteln in Deutschland Realität und Erfordernis nach Leitlinien. Der Anaesthesist 2011/4;60(4):312

Szalay G., Meyer C., Schaumberg A., Mann V., Weigand M.A., Schnettler R.: Stabilisierung instabiler Beckenfrakturen im Schockraum mittels pneumatischer Beckenschlinge. Notfall und Rettungsmedizin 2009; 13:47-51

Steppan J, Hofer S, Funke B, Brenner T, Henrich M, Martin E, Weitz J, Hofmann U, Weigand MA.
Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix.
J Surg Res. 2009 May 20. [Epub ahead of print] (IF: 1,875)

Eisenbach C, Encke J, Merle U, Gotthardt D, Weiss KH, Schneider L, Latanowicz S, Spiegel M, Engelmann G, Stremmel W, Büchler MW, Schmidt J, Weigand MA, Sauer P.
An early increase in gamma glutamyltranspeptidase and low aspartate aminotransferase peak values are associated with superior outcomes after orthotopic liver transplantation.
Transplant Proc. 2009 Jun;41(5):1727-30. (IF: 1,055)

Hofer S, Brenner T, Bopp C, Steppan J, Lichtenstern C, Weitz J, Bruckner T, Martin E, Hoffmann U, Weigand MA.
Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction.
Crit Care. 2009 Jun 18;13(3):R93. [Epub ahead of print] (4,553)

Hofer S, Rosenhagen C, Nakamura H, Yodoi J, Bopp C, Zimmermann JB, Goebel M, Schemmer P, Hoffmann K, Schulze-Osthoff K, Breitkreutz R, Weigand MA.
Thioredoxin in human and experimental sepsis.
Crit Care Med. 2009 Jul;37(7):2155-9. (IF: 6,594)


Koch L, Hofer S, Weigand MA, Frommhold D, Poeschl J.
Lipopolysaccharide-induced activation of coagulation in neonatal cord and adult blood monitored by thrombelastography.
Thromb Res. 2009 May 26. [Epub ahead of print] (IF: 2,449)

Seiler CM, Deckert A, Diener MK, Knaebel HP, Weigand MA, Victor N, Büchler MW
Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalence trial (POVATI: ISRCTN60734227)
Ann Surg 2009; 249:913-920 (IF: 8,460)

Humpert PM, Lukic IK, Thorpe SR, Hofer S, Awad EM, Andrassy M, Deemer EK, Kasper M, Schleicher E, Schwaninger M, Weigand MA, Nawroth PP, Bierhaus A
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis
J Leukoc Biol 2009; Apr 28 [Epub ahead of print] (IF 4,128)

Scheuren K, Wente MN, Hainer C, Scheffler M, Lichtenstern C, Martin E, Schmidt J, Bopp C, Weigand MA
Leftventricular enddiastolic area is a measure of cardiac preload in patients with early septic shock
Eur J Anaesthesiol 2009; Apr 22 [Epub ahead of print] (IF 1,435)

Bopp C, Hofer S, Bouchon A, Zimmermann JB, Martin E, Weigand MA
Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation
Eur J Anaesthesiol 2009; 26:504-507 (IF 1,435)

Rahbari NN, Zimmermann JB, Schmidt T, Koch M, Weigand MA, Weitz J
Meta-analysis of standard, restrictive and supplemental fluid administration in colorectal surgery
Br J Surg 2009; 96:331-341 (IF 4,304)
Hoffmann K, Weigand MA, Hillebrand N, Büchler MW, Schmidt J, Schemmer P
Is veno-venous bypass still needed during liver transplantation? A review of the literature
Clin Transplant 2009; 23:1-8 (IF 1,923)

Hofer S, Steppan J, Wagner T, Funke B, Lichtenstern C, Martin E, Graf BM, Bierhaus A, Weigand MA
Central sympatholytics prolong survival in experimental sepsis
Crit Care 2009 Feb 5;13(1):R11 [Epub ahead of print] (IF 3,83)

Bopp C, Hofer S, Klein A, Weigand MA, Martin E, Gust R.
A liberal preoperative fasting regimen improves patient comfort and satisfaction with anesthesia care in day-stay minor surgery
Minerva Anestesiol 2009 Feb 4 [Epub ahead of print] (IF -)

Mühling J, Tussing F, Nickolaus KA, Matejec R, Henrich M, Harbach H, Wolff M, Weismüller K, Engel J, Welters ID, Langefeld TW, Fuchs M, Weigand MA, Heidt MC
Effects of alpha-ketoglutarate on neutrophil intracellular amino and alpha-keto acid profiles and ROS production
Amino Acids 2009 Jan 17 [Epub ahead of print] (IF 2,2)

Störzinger D, Swoboda S, Lichtenstern C, Müller C, Weigand MA, Hoppe-Tichy T
Development and validation of a high-performance liquid chromatography assay for posaco-nazole utilizing solid-phase extraction
Clin Chem Lab Med 2008; 46:1747-51 (IF 1,741)

Kayhan N, Funke B, Conzelmann LO, Winkler H, Hofer S, Steppan J, Schmidt H, Bardenheuer H, Vahl CF, Weigand MA
The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation
Crit Care 2008;12(5):R125 [Epub 2008 Oct 13] (IF 3,83)

Störzinger D, Lichtenstern C, Swoboda S, Weigand MA, Hoppe-Tichy T
Posaconazole in intensive care patients I: invasive fungal infections in surgical intensive care and case presentation
Mycoses 2008; 51(Suppl. 2):52-57 (IF 0,959)

Hainer C, Wente MN, Hallscheidt PJ, Schmidt J, Martin E, Büchler MW, Weigand MA
Morphine-induced acute lung injury
J Clin Anesth 2008; 20:300-303 (IF 1,028)

Lichtenstern C, Nguyen TH, Schemmer P, Hoppe-Tichy T, Weigand MA
Efficacy of caspofungin in invasive candidiasis and candidemia – de-escalation strategy
Mycoses 2008; 51(Suppl. 1):35-46 (IF 0,959)

Zink W, Kaess M, Hofer S, Plachky J, Zausig YA, Sinner B, Weigand MA, Fink RHA, Graf BM
Alterations in intracellular Ca2+ -homeostasis of skeletal muscle fibers during sepsis
Crit Care Med 2008; 36:1559-1563 (IF 6,599)

Hainer C, Böckler D, Bernhard M, Scheuren K, Stein KM, Rauch H, Martin E, Weigand MA
Stumpfe traumatische Aortenverletzung – Stellenwert der transösophagealen Echokardiographie [Blunt traumatic aortic injury: Importance of transesophagealechocardiography]
Anaesthesist 2008; 57: 262-268 (IF 0,863)

Bopp C, Bierhaus A, Hofer S, Bouchon A, Nawroth PP, Martin E, Weigand MA
Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis
Crit Care 2008; 12 (1):201; Epub 2008 Jan 9 (IF 3,116)

Swoboda S, Ober M, Hainer C, Lichtenstern C, Seiler C, Wendt C, Hoppe-Tichy T, Büchler M, Weigand MA
Tigecycline for the treatment of patients with severe sepsis or septic shock: a drug use evaluation in a surgical intensive care unit
J Antimicrob Chemother 2008; 61:729-733; Epub Jan 25 (IF 3,891)

Schemmer P, Nickkholgh A, Schneider H, Sobirey M, Weigand M, Koch M, Weitz J, Buchler MW
PORTAL: Pilot study on the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection: a double-blind randomized placebo-controlled trial
BMC Surg 2008, Jan 23; 8(1):2 (IF -)

Hofer S, Bopp C, Hoerner C, Plaschke K, Faden RM, Martin E, Bardenheuer HJ, Weigand MA
Injury of the blood brain barrier and up-regulation of ICAM-1 in polymicrobial sepsis
J Surg Res 2008; 146:276-281; Epub Aug 23 (IF 2,038)

Welsch T, Frommhold K, Hinz U, Weigand MA, Kleeff J, Friess H, Büchler MW, Schmidt J
Persisiting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications
Surgery 2008; 143:20-28 (IF 2,977)

Hofer S, Eisenbach C, Lukic IK, Schneider L, Bode K, Brueckmann M, Mautner S, Wente MN, Encke J, Werner J, Dalpke AH, Stremmel W, Nawroth PP, Martin E, Krammer PH, Bier-haus A, Weigand MA
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis
Crit Care Med 2008; 36:404-408 (IF 6,599)

Michalski CW, Gorbachevski A, Erkan M, Reiser C, Deucker S, Bergmann F, Giese T, Wei-gand M, Giese NA, Friess H, Kleeff J
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis
J Transl Med 2007; Dec 5; 5(1):63 (IF 2,94)

Plaschke K, von Haken R, Scholz M, Engelhardt R, Brobeil A, Martin E, Weigand MA
Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s)
Intensive Care Med 2008; 34:431-436; Epub 2007 Nov 9 (IF 4,406)

Plaschke K, Hill H, Engelhardt R, Thomas C, von Haken R, Scholz M, Kopitz J, Bardenheuer HJ, Martin E, Weigand MW
In contrast to EEG changes serum anticholinergic activity (SAA) fails to reflect clinical dia-gnosis of delirium in intensive care unit patients
Anaesthesia 2007; 62:1217-1223 (IF 2,427)

Bopp C, Hofer S, Weitz J, Bierhaus A, Nawroth PP, Martin E, Büchler MW, Weigand MA
sRAGE is elevated in septic patients and associated with patients outcome
J Surg Res 2008; 147:79-83; Epub 2007 Aug 22 (IF 2,038)

Swoboda S, Ober M, Anagnostakos K, Geiss HK, Weigand MA, Hoppe-Tichy T
A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies
Clin Chem Lab Med 2007; 45:1019-1022 (IF 1,725)

Eisenbach C, Schonfeld AH, Vogt N, Wente MN, Encke J, Stremmel W, Martin E, Pfenninger E, Weigand MA
Pharmacodynamics and organ storage of hydroxyethyl starch in acute hemodilution in pigs: Influence of molecular weight and degree of substitution
Intensive Care Med 2007; 33:1637-1644. [Epub 2007 Jun 7] (IF 4,406)

Nguyen TH, Hoppe-Tichy T, Geiss HK, Rastall A, Swoboda S, Schmidt J, Weigand MA
Factors influencing caspofungin plasma concentrations in patients of a surgical intensive care unit
J Antimicrob Chemother 2007; 60:100-106. [Epub 2007 May 24] (IF 3,891)

Vogel J, Weigand MA, Behrens A, Wagner EF, Schorpp-Kistner M, Zimmermann M, Schen-kel J
Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action
Brain Res 2007; 1151:12-19 [Epub 2007 Mar 13] (IF 2,341)

Plaschke K, Thomas C, Engelhardt R, Teschendorf P, Hestermann U, Weigand MA, Martin E, Kopitz J
Significant correlation between plasma and CSF anticholinergic activity in presurgical patients
Neurosci Lett 2007; 417:16-20 [Epub 2007 Feb 9] (IF 2,092)

Swoboda S, Hoppe-Tichy T, Geiss HK, Hainer C, Nguyen TH, Knaebel HP, Weigand MA
Septischer Schock durch Vancomycin-resistente Enterokokken. Tigecyclin-Monotherapie
Anaesthesist 2007; 56:169-174 (IF 0,863)

Lichtenstern C, Geiss HK, Böttiger BW, Weigand MA
Antimykotische Therapie in der Intensimedizin
Intensivmed.up2date 2007; 3:21-40 (IF 0)

Lichtenstern C, Schmidt J, Knaebel HP, Martin E, Buchler MW, Weigand MA
Postoperative bacterial/fungal infections: a challenging problem in critically ill patients after abdominal surgery
Dig Surg 2007; 24:1-11 [Epub 2007 Jan 25] (IF 1,397)

Ritsou E, Breitkreuz R, Benner A, Bohler T, Weigand MA, Walczak H, Gougeon ML, Krammer PH
CD4/CXCR4-mediated cell death in AIDS

Cell Death Differ 2007; 14:634-636 [Epub 2006 Nov 3] (IF 7,463)

Heller AR, Rothermel J, Weigand MA, Plaschke K, Schmeck J, Wendel M, Bardenheuer HJ, Koch T
Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.
Eur J Anaesthesiol 2007; 24:258-266 [Epub 2006 Nov 10] (IF 1,169)

Weitz J, Weigand MA, Kienle P, Jager D, Buchler MW, Martin E
Stellenwert der Anästhesie in multimodalen onkologischen Therapiekonzepten [Importance of anesthesia in multimodal oncologic therapeutical concepts]
Anaesthesist 2006; 55:1299-1306 (IF 0,863)
Hainer C, Bernhard M, Scheuren K, Rauch H, Weigand MA
Echokardiographie bei der akuten hämodynamischen Instabilität [Echocardiography during acute hemodynamic instability]
Anaesthesist 2006; 55:1117-1131; quiz 1132 (IF 0,863)

Morath C, Miftari N, Dikow R, Hainer C, Zeier M, Schwenger V, Weigand MA
Nierenersatztherapie auf Intensivstation [Renal replacement therapy in the intensive care unit]
Anaesthesist 2006; 55:901-914 (IF 0,863)

Zausig YA, Weigand MA, Graf BM

Perioperatives Flüssigkeitsmanagement – eine Analyse der aktuellen Studienlage
Anaesthesist 2006; 55:371-390 (IF 0,863)

Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
Cell Death Differ 2004; 11 Suppl 1:S86-S96 (IF 7,463)

Liliensiek B*, Weigand MA*, Bierhaus A*, Nicklas W; Kasper M, Hofer S, Plachky J, Gröne HJ, Kurschus FC, Schmidt AM, Yan SD, Martin E, Schleicher E, Stern DM, Hammerling GJ, Nawroth PP, Arnold B
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
J Clin Invest 2004;113:1641-1650 (IF 15,754)
*These authors contributed equally to this work

Washburn B*, Weigand MA*, Grosse-Wilde A, Janke M, Stahl H, Rieser E, Sprick MR, Schirrmacher V, Walczak H
TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus
J Immunol 2003; 170:1814-1821 (IF 6,293)
*Both authors contributed equally to this work

Li-Weber M, Weigand MA, Giaisi M, Suss D, Treiber MK, Baumann S, Ritsou E, Breitkreuz R, Krammer PH
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
J Clin Invest 2002; 110:681-690 (IF 15,754)

Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
EMBO J 2002; 21:4520-4530 (IF 10,086)

Muerkoster S, Weigand MA, Choi C, Walczak H, Schirrmacher V, Umansky V
Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumor cells
Br J Cancer 2002; 86:828-836 (IF 4,459)

Weigand MA, Plachky J, Thies JC, Spies-Martin D, Otto G, Martin E, Bardenheuer HJ
N-acetylcysteine attenuates the increase in alpha-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation
Transplantation 2001; 72:694-698 (IF 3,972)

Plaschke K, Grant M, Weigand MA, Zuchner J, Martin E, Bardenheuer HJ
Neuromodulatory effect of propentofylline on rat brain under acute and long-term hypoperfusion
Br J Pharmacol 2001, 133:107-116 (IF 3,825)

Bouchon A, Facchetti F*, Weigand MA*, Colonna M
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
Nature 2001, 410:1103-1107 (IF 26,681)
*Both authors contributed equally to this work