Prof. Dr. med. Claus Wittekindt
Kommissarischer Direktor Tel.: 0641/985-43701 Fax: 0641/985-43709 claus.wittekindt@hno.med.uni-giessen.de
Akademischer und beruflicher Werdegang:
| 1990 | Allgemeine Hochschulreife |
| 1990 - 1992 | Ersatzdienst, AWO Hürth |
| ab Oktober 1992 | Studium der Medizin, Universität zu Köln |
| ab Oktober 1994 | Studium der Sportwissenschaften, Deutsche Sporthochschule Köln |
| ab März 1998 | Studium der Zahnmedizin, Universität Marburg |
| 1998 | Medizinisches Staatsexamen, Universität zu Köln |
| 1998 | Approbation als Arzt im Praktikum |
| 1998 - 1999 |
Arzt im Praktikum, Klinik für Hals-Nasen-Ohrenheilkunde, |
| 1999 | Approbation als Arzt |
| 2000 | Promotion durch die Hohe Medizinische Fakultät der Universität zu Köln. Thema der Dissertation: Eignung typspezifischer Oligopeptide zur Diagnose von HSV-1- und HSV-2-Infektionen |
| 1999-2001 | Wissenschaftlicher Mitarbeiter, Jean-Urmacher-Institut für klinische HNO-Forschung |
| 2003 | Facharzt für Hals-Nasen-Ohrenheilkunde |
| 2001-2006 | Wissenschaftlicher Mitarbeiter, Klinik für Hals-Nasen-Ohrenheilkunde der Universität zu Köln |
| 2006-2010 |
Wissenschaftlicher Mitarbeiter, Klinik für Hals-Nasen-Ohrenheilkunde der Universität zu Jena |
| 2008 | Habilitation für das Fach Hals-Nasen-Ohrenheilkunde |
| 2010 | Wissenschaftlicher Mitarbeiter, Klinik für Hals-Nasen-Ohrenheilkunde des Universitätsklinikums Gießen und Marburg, Standort Gießen Ernennung zum Leitenden Oberarzt |
| 2014 | Verleihung des Titels: Außerplanmäßiger Professor |
Mitgliedschaft in wissenschaftlichen und medizinischen Fachgesellschaften:
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Deutsche Gesellschaft für Hals-Nasen-Ohrenheilkunde Kopf- und Hals-Chirurgie e.V. |
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Arbeitskreis Botulinumtoxin der deutschen Gesellschaft für Neurologie |
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European Laryngological Society |
| 1. | Wittekindt C, Jungehulsing M, Theissen P, Brochhagen HG. FDG PET imaging of malignant paraganglioma of the neck. The Annals of otology, rhinology, and laryngology 1999;108:909-912 |
| 2. | Hess A, Bloch W, Wittekindt C, Siodladczek J, Addicks K, Michel O. Immunohistochemical detection of vascular endothelial growth factor (VEGF) and VEGF-receptors Flt-1 and KDR/Flk-1 in the vestibule of guinea pigs. Neuroscience letters 2000;280:147-150 |
| 3. | Hess A, Michel O, Kopec T, Wittekindt C, Bloch W, Stennert E, Addicks K. Detection of extracellular signal-regulated kinase1/2 in the inner ear of guinea pigs. Neuroscience letters 2000;289:72-74 |
| 4. | Sittel C, Thumfart WF, Pototschnig C, Wittekindt C, Eckel HE. Textured polydimethylsiloxane elastomers in the human larynx: safety and efficiency of use. Journal of biomedical materials research 2000;53:646-650 |
| 5. | Wittekindt C, Fleckenstein B, Wiesmuller K, Eing BR, Kuhn JE. Detection of human serum antibodies against type-specifically reactive peptides from the N-terminus of glycoprotein B of herpes simplex virus type 1 and type 2 by surface plasmon resonance. Journal of virological methods 2000;87:133-144 |
| 6. | Wittekindt C, Jungehulsing M, Fischbach R, Landwehr P. [Chronic recurrent parotitis in childhood in monozygotic twins. Magnetic resonance sialography]. Hno 2000;48:221-225 |
| 7. | Bachmann G, Su J, Zumegen C, Wittekindt C, Michel O. [Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection]. Hno 2001;49:538-542 |
| 8. | Streppel M, Wittekindt C, von Wedel H, Walger M, Schondorf HJ, Michel O, Stennert E. Progressive hearing loss in hearing impaired children: immediate results of antiphlogistic--rheologic infusion therapy. International journal of pediatric otorhinolaryngology 2001;57:129-136 |
| 9. | Wittekindt C, Schondorf J, Stennert E, Jungehulsing M. Duplication of the external auditory canal: a report of three cases. International journal of pediatric otorhinolaryngology 2001;58:179-184 |
| 10. | Klussmann JP, Knoedgen R, Wittekindt C, Damm M, Eckel HE. Complications of suspension laryngoscopy. The Annals of otology, rhinology, and laryngology 2002;111:972-976 |
| 11. | Wittekindt C, Hess A, Bloch W, Sultanie S, Michel O. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol 2002;259:294-298 |
| 12. | Wittekindt C, Kassens G, Bramlage S, Eckel HE, Goldschmidt O, Schrappe M, Streppel M. [Quality assurance indicators in an ENT practice]. Hno 2002;50:553-559 |
| 13. | Wittekindt C, Kribs A, Roth B, Streppel M. Rupture of the larynx in a newborn. Obstetrics and gynecology 2002;99:904-906 |
| 14. | Eckel HE, Wittekindt C, Klussmann JP, Schroeder U, Sittel C. Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysis. The Annals of otology, rhinology, and laryngology 2003;112:103-108 |
| 15. | Guntinas-Lichius O, Wittekindt C. The role of growth factors for disease and therapy in diseases of the head and neck. DNA and cell biology 2003;22:593-606 |
| 16. | Schroeder U, Motzko M, Wittekindt C, Eckel HE. Hoarseness after laryngeal blunt trauma: a differential diagnosis between an injury to the external branch of the superior laryngeal nerve and an arytenoid subluxation. A case report and literature review. Eur Arch Otorhinolaryngol 2003;260:304-307 |
| 17. | Su J, Bachmann G, Tang A, Zumegen C, Michel O, Wittekindt C. [The different levels of prednisolone in perilymph after local and systemic treatment]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 2003;17:615-617 |
| 18. | Wittekindt C, Drebber U, Klussman JP, Guntinas-Lichius O. [Vascularized tumor of the scalp]. Hno 2003;51:737-738 |
| 19. | Klussmann JP, Dinh S, Guntinas-Lichius O, Wittekindt C, Weissenborn S, Wieland U, Dienes HP, Hoffmann T, Smith E, Turek L, Speel EJ, Pfister HJ. [HPV-associated tonsillar cancer. An update]. Hno 2004;52:208-218 |
| 20. | Schroder U, Dries V, Klussmann JP, Wittekindt C, Eckel HE. Successful adjuvant tamoxifen therapy for estrogen receptor-positive metastasizing sweat gland adenocarcinoma: need for a clinical trial? The Annals of otology, rhinology, and laryngology 2004;113:242-244 |
| 21. | Stennert E, Wittekindt C, Klussmann JP, Arnold G, Guntinas-Lichius O. Recurrent pleomorphic adenoma of the parotid gland: a prospective histopathological and immunohistochemical study. The Laryngoscope 2004;114:158-163 |
| 22. | Stennert E, Wittekindt C, Klussmann JP, Guntinas-Lichius O. New aspects in parotid gland surgery. Otolaryngologia polska 2004;58:109-114 |
| 23. | Wittekindt C, Liu WC, Klussmann JP, Guntinas-Lichius O. Botulinum toxin type A for the treatment of chronic neck pain after neck dissection. Head & neck 2004;26:39-45 |
| 24. | Beutner D, Wittekindt C, Huttenbrink KB. [Painful swelling of the soft tissue of the neck]. Hno 2005;53:637-638 |
| 25. | Preuss SF, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D, Reineck S, Huttenbrink KB. [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle]. Hno 2005;53:876-878 |
| 26. | Wittekindt C, Gultekin E, Weissenborn SJ, Dienes HP, Pfister HJ, Klussmann JP. Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Advances in oto-rhino-laryngology 2005;62:72-80 |
| 27. | Beutner D, Preuss SF, Schulz AI, Wittekindt C, Quante G, Huttenbrink KB. [An isolated retropharyngeal bone as a rare cause of dysphagia.]. Hno 2006;54:473-476 |
| 28. | Beutner D, Wittekindt C, Dinh S, Huttenbrink KB, Guntinas-Lichius O. Impact of lateral parotidectomy for benign tumors on quality of life. Acta oto-laryngologica 2006;126:1091-1095 |
| 29. | Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E. Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. The Laryngoscope 2006;116:534-540 |
| 30. | Preuss SF, Wittekindt C. Do homeopathic drugs affect microcirculation in vertigo? Microvascular research 2006;71:141 |
| 31. | Preuss SF, Wittekindt C. [Osteoma of the frontal sinus.]. Deutsche medizinische Wochenschrift (1946) 2006;131:2013-2014 |
| 32. | Preuss SF, Wittekindt C, Beutner D, Huttenbrink KB. Successful OK-432 therapy for a supraclavicular lymphocele: report of a case. Eur Arch Otorhinolaryngol 2006;263:692-694 |
| 33. | Quante G, Wittekindt C, Beutner D, Preuss SF, Damm M, Huttenbrink KB. [Chronic-persistent infection of the auricle]. Hno 2006;54:35-36 |
| 34. | Wittekindt C, Liu WC, Hampl JA, Guntinas-Lichius O. Radiology quiz case 1: Intracranial schwannoma originating from the greater petrosal nerve. Archives of otolaryngology--head & neck surgery 2006;132:102, 104 |
| 35. | Wittekindt C, Liu WC, Preuss SF, Guntinas-Lichius O. Botulinum toxin A for neuropathic pain after neck dissection: a dose-finding study. The Laryngoscope 2006;116:1168-1171 |
| 36. | Wittekindt C, Luers JC, Drebber U, Guntinas-Lichius O, Huttenbrink KB. [ANCA-negative subglottic laryngeal stenosis in childhood.]. Hno 2006 |
| 37. | Wittekindt C, Michel O, Streppel M, Roth B, Quante G, Beutner D, Guntinas-Lichius O. Lymphatic malformations of the head and neck: introduction of a disease score for children, Cologne Disease Score (CDS). International journal of pediatric otorhinolaryngology 2006;70:1205-1212 |
| 38. | Wittekindt C, Sittel C, Kvasnicka HM, Eckel HE. Immunohistochemistry of whole-organ sections of advanced human laryngeal cancer. Eur Arch Otorhinolaryngol 2006;263:741-746 |
| 39. | Preuss SF, Klussmann JP, Wittekindt C, Damm M, Semrau R, Drebber U, Guntinas-Lichius O. Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinoma. Eur J Surg Oncol 2007;33:358-363 |
| 40. | Preuss SF, Klussmann JP, Wittekindt C, Drebber U, Beutner D, Guntinas-Lichius O. Submandibular gland excision: 15 years of experience. J Oral Maxillofac Surg 2007;65:953-957 |
| 41. | Wittekindt C, Luers JC, Klussmann JP, Huttenbrink KB. Pyoderma gangrenosum in the head and neck. Archives of otolaryngology--head & neck surgery 2007;133:83-85 |
| 42. | Wittekindt C, Sittel C, Greiss J, Drebber U, Eckel HE, Preuss SF. Mapping of Ki-67 protein distribution on whole organ serial sections of the larynx. Acta oto-laryngologica 2007:1-6 |
| 43. | Wittekindt C, Streubel K, Arnold G, Stennert E, Guntinas-Lichius O. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head & neck 2007;29:822-828 |
| 44. | Beutner D, Wittekindt C, Guntinas-Lichius O. In reference to limited parotidectomy: the role of extracapsular dissection in parotid gland neoplasms. The Laryngoscope 2008;118:379; author reply 379-380 |
| 45. | Grosheva M, Wittekindt C, Guntinas-Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. The Laryngoscope 2008;118:394-397 |
| 46. | Grosheva M, Wittekindt C, Pototschnig C, Lindenthaler W, Guntinas-Lichius O. Evaluation of peripheral vocal cord paralysis by electromyography. The Laryngoscope 2008;118:987-990 |
| 47. | Helmstaedter V, Wittekindt C, Huttenbrink KB, Guntinas-Lichius O. Safety and efficacy of botulinum toxin therapy in otorhinolaryngology: experience from 1,000 treatments. The Laryngoscope 2008;118:790-796 |
| 48. | Kostka E, Wittekindt C, Guntinas-Lichius O. [Tongue coating, mouth odor, gustatory sense disorder - earlier and new treatment options by means of tongue scraper]. Laryngo- rhino- otologie 2008;87:546-550 |
| 49. | Luers JC, Wittekindt C, Streppel M, Guntinas-Lichius O. Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta oncologica (Stockholm, Sweden) 2008:1-5 |
| 50. | Preuss SF, Weinell A, Molitor M, Stenner M, Semrau R, Drebber U, Weissenborn SJ, Speel EJ, Wittekindt C, Guntinas-Lichius O, Hoffmann TK, Eslick GD, Klussmann JP. Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer. British journal of cancer 2008;98:627-632 |
| 51. | Preuss SF, Wittekindt C. Comments on the article by Redaelli de Zinis et al.: "Management and prognostic factors of recurrent pleomorphic adenoma of the parotid gland: personal experience and review of the literature". Eur Arch Otorhinolaryngol 2008 |
| 52. | Wittekindt C, Sittel C, Greiss J, Drebber U, Eckel HE, Preuss SF. Mapping of Ki-67 protein distribution on whole organ serial sections of the larynx. Acta oto-laryngologica 2008;128:207-212 |
| 53. | Lüers JC, Wittekindt C, Streppel M, Guntinas-Lichius O. Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 2009;48(1):132-6. |
| 54. | Schroeder U, Dietlein M, Wittekindt C, Ortmann M, Stuetzer H, Vent J, Jungehuelsing M, Krug B. Is there a need for positron emission tomography imaging to stage the N0 neck in T1-T2 squamous cell carcinoma of the oral cavity or oropharynx?. Ann Otol Rhinol Laryngol. 2008 Nov;117(11). |
| 55. | Melle C, Ernst G, Winkler R, Schimmel B, Klussmann JP, Wittekindt C, Guntinas-Lichius O, von Eggeling F. Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: Identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. Proteomics. 2009 Mar 31;9(8):2193-2201. |
| 56. | Wittekindt C, Burmeister HP, Guntinas-Lichius O. [Diagnostic and therapy of salivary gland diseases: relevant aspects for the pathologist from the clinical perspective]. Pathologe 2009;30:424-431. |
| 57. | Goxhufi A, Wittekindt C, Guntinas-Lichius O: [monosymptomatic aphagia from dorsolateral medullary infarction (wallenberg syndrome)]. Laryngo- rhino- otologie 2009;88:599-600. |
| 58. | Bohne S, Koscielny S, Burmeister HP, Guntinas-Lichius O, Wittekindt C. [Bilateral deafness and unilateral facial nerve palsy as presenting features of Wegener's granulomatosis : a case report]. Hno 2010;58:480-483. |
| 59. | Grosheva M, Beutner D, Volk GF, Wittekindt C, Guntinas-Lichius O. [Idiopathic facial palsy]. Hno 2010;58:419-425. |
| 60. | Kostka E, Guntinas-Lichius O, Wittekindt C. [Unilateral recurrent tumor of the nasal cavity and the paranasal sinuses]. Laryngo- rhino- otologie 2010;89:36-38. |
| 61. | Wittekindt C, Guntinas-Lichius O: [benign lesions of the larynx]. Laryngorhinootologie 2010;89:491-507, quiz 508-509. |
| 62. | Volk GF, Pantel M, Guntinas-Lichius O, Wittekindt C: Prognostic value of anterior rhinomanometry in diode laser turbinoplasty. Archives of otolaryngology--head & neck surgery 2010;136:1015-1019. |
| 63. | Kroll T, Helbig M, Klussmann JP, Wittekindt C: [intraductal application of levovist(r) in salivary glands of animals.]. Laryngorhinootologie. 2012 Apr;91(4):229-32. Epub 2011 Jul 4. German. |
| 64. | Bitter T, Volk GF, Lehmann P, Wittekindt C, Guntinas-Lichius O: [progressive hoarseness]. Hno 2011;59:283-285. |
| 65. | Kostka E, Guntinas-Lichius O, Runnebaum IB, Fuller J, Kalff R, Wittekindt C: [space-occupying tumor of the temporal region with facial nerve palsy, vestibular dysfunction and hearing loss]. Hno 2011;59:1219-1223 |
| 66. | Pantel M, Volk GF, Guntinas-Lichius O, Wittekindt C: Botulinum toxin type b for the treatment of a sialocele after parotidectomy. Head Neck. 2011 Jun 17. doi: 10.1002/hed.21778. [Epub ahead of print]. |
| 67. | Wittekindt C, Wagner S, Klussmann JP. [HPV-associated head and neck cancer. The basics of molecular and translational research]. HNO 2011 Sep;59(9):885-92. Review. |
| 68. |
Pantel M, Wittekindt C, Altendorf-Hofmann A, Boeger D, Buentzel J, Esser D, Mueller A, Wendt TG, Guntinas-Lichius O: Diversity of treatment of t2n0 glottic cancer of the larynx: Lessons to learn from epidemiological cancer registry data. Acta oto-laryngologica 2011;131:1205-1213. |
| 69. | Poller K, Volk GF, Wittekindt C, Meissner W, Guntinas-Lichius O: [estimation of postoperative pain after tonsillectomy in adults using quips: An instrument to improve postoperative pain management]. Laryngorhinootologie. 2011 Feb;90(2):82-9. |
| 70. | Wittekindt C, Jovanovic N, Guntinas-Lichius O: Expression of matrix metalloproteinase-9 (mmp-9) and blood vessel density in laryngeal squamous cell carcinomas. Acta oto-laryngologica 2011;131:101-106. |
| 71. | Wittekindt D, Wittekindt C, Schneider G, Meissner W, Guntinas-Lichius O: Postoperative pain assessment after septorhinoplasty. Eur Arch Otorhinolaryngol. 2011 Dec 1. [Epub ahead of print]. |
| 72. | Bitter T, Pantel M, Dittmar Y, Guntinas-Lichius O, Wittekindt C: Stent migration to the ileum-a potentially lethal complication after montgomery salivary bypass tube placement for hypopharyngeal stenosis after laryngectomy. Head & neck 2012;34:135-137. |
| 73. | Wagner S, Mayer C, Wittekindt C, Klussmann JP: [human papillomavirus (hpv) and head and neck cancer.]. Hautarzt. 2012 Jan;63(1):24-9. |
| 74. | Poller K, Pantel M, Wittekindt C, Meissner W, Guntinas-Lichius O: Postoperative pain assessment after functional endoscopic sinus surgery (FESS) for chronic pansinusitis Eur Arch Otorhinolaryngol. 2011 Dec 1. [accepted on 22-03-2012]. |
| 75. | Wittekindt C, Wagner S, Mayer CS, Klußmann JP. [Basics of Tumor Development and Importance of Human Papilloma Virus (HPV) for Head and Neck Cancer]. Laryngorhinootologie 2012 Mar;91 Suppl 1:S1-S26. Epub 2012 Mar 28. |
| 76. | Wittekindt D, Wittekindt C, Meissner W, Guntinas-Lichius O. [Postoperative pain assessment after middle ear surgery]. HNO. 2012 Nov;60(11):974-84. doi: 10.1007/s00106-012-2556-4. German. |
| 77. | Kroll T, Finkensieper M, Sharma SJ, Guntinas-Lichius O, Wittekindt C. Short-term outcome and patient satisfaction after sialendoscopy. Eur Arch Otorhinolaryngol. 2013 Mar 9. [Epub ahead of print] |
| 78. | Sharma SJ, Kreisel M, Kroll T, Gattenloehner S, Klussmann JP, Wittekindt C. Extracardiac juvenile rhabdomyoma of the larynx: a rare pathological finding. Eur Arch Otorhinolaryngol. 2013 Feb;270(2):773-6. doi: 10.1007/s00405-012-2245-7. Epub 2012 Nov 5. |
| 79. | Peter F, Wittekindt C, Finkensieper M, Kiehntopf M, Guntinas-Lichius O. Prognostic impact of pretherapeutic laboratory values in head and neck cancer patients. J Cancer Res Clin Oncol. 2013 Jan;139(1):171-8. doi: 10.1007/s00432-012-1320-1. Epub 2012 Sep 25. |
| 80. | Kroll T, Finkensieper M, Hauk H, Guntinas-Lichius O, Wittekindt C. [Sialendoscopy--learning curve and nation-wide survey in German ENT-departments]. Laryngorhinootologie. 2012 Sep;91(9):561-5. doi: 10.1055/s-0032-1314880. Epub 2012 Jul 6. German. |
| 81. | Sharma SJ, Linke JJ, Kroll T, Klußmann JP, Guntinas-Lichius O, Wittekindt C. [Current practice of tumour endoscopy in German ENT-clinics]. Laryngorhinootologie. 2013 Mar;92(3):166-9. doi: 10.1055/s-0032-1331759. Epub 2013 Jan 30. German |