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Team

Visitenkarte


Prof. Dr. Veronika Grau

Leiterin der Sektion Experimentelle Chirurgie

Tel.: 0641/985-44791
Fax: 0641/985-44769

Veronika.Grau@chiru.med.uni-giessen.de

Mitgliedschaften

Excellence Cluster Cardio-Pulmonary System (ECCPS)
http://www.eccps.de

LOEWE-Zentrum UGMLC
(Universities of Giessen and Maburg Lung Center)
http://www.ugmlc.de

Graduiertenkolleg “Signaling Mechanisms in Lung Physiology and Disease” (SMLPD)
http://www.uni-giessen.de/cms/ueber-uns/jlu/graduiertenkollegs/signaling

Deutsches Zentrum für Lungenforschung
http://www.dzg-lungenforschung.de

LOEWE-Programm
Non-neuronale cholinerge Systeme NNCS
http://www.uni-giessen.de/cms/fbz/fb11/forschung/schwerpunkte/loewe/nncs

Publikationen

Grau V, Richter K, Hone AJ, McIntosh JM.
Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes.
Front Pharmacol. 2019 Jan 7;9:1499.  eCollection 2018.
Abstract

Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.
C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.
Front Immunol. 2018 Jul 30;9:1604.
Abstract


Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, Wichmann S, Wilker S, Magel I, Sander M, McIntosh JM, Padberg W, Grau V.
Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells.
Molecules. 2018 Aug 8;23(8). pii: E1979.
Abstract

Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V.
Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors.
Front Immunol. 2018 Apr 25;9:877.
Abstract

Hiller SD, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, Wilker S, Fuchs-Moll G, Manzini I, Schmalzing G, Kummer W, Padberg W, McIntosh JM, Damm J, Zakrzewicz A, Grau V.
β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells.
Int J Mol Sci. 2018 Apr 10;19(4). pii: E1126.
Abstract

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539.
Abstract

Amati AL, Zakrzewicz A, Siebers K, Wilker S, Heldmann S, Zakrzewicz D, Hecker A, McIntosh JM, Padberg W, Grau V.
Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells.
Mediators Inflamm. 2017;2017:1434872.
Abstract

Schmitz J, Zakrzewicz A, Wilker S, Kuncová J, Hecker A, Grau V, Padberg W, Holler JPN.
Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts.
Transpl Immunol. 2017 Aug;43-44:49-53.
Abstract

Backhaus S, Zakrzewicz A, Richter K, Damm J, Wilker S, Fuchs-Moll G, Küllmar M, Hecker A, Manzini I, Ruppert C, McIntosh JM, Padberg W, Grau V.
Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors.
J Lipid Res. 2017 Jun;58(6):1055-1066.
Abstract

Soultanova A, Mikulski Z, Pfeil U, Grau V,, Kummer W.
Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
PLoS One. 2016 Oct 13;11(10):e0163483.
Abstract


Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S.
α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils.
Mol Med. 2016 Jul 13;22. [Epub ahead of print]
Abstract


Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V.
Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.
Sci Rep. 2016 Jun 28;6:28660.
Abstract


Grau V, Zeuschner P, Immenschuh S, Bockmeyer CL, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker JU.
Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy.
Transplantation. 2016 May;100(5):1004-14.
Abstract

Koch C, Hecker A, Grau V, Padberg W, Wolff M, Henrich M.
Intravenous immunoglobulin in necrotizing fasciitis - A case report and review of recent literature.
Ann Med Surg (Lond). 2015 Aug 1;4(3):260-3
Abstract

Hecker A, Küllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V.
Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.
J Immunol. 2015 Sep 1;195(5):2325-34
Abstract


Zakrzewicz A, Atanasova S, Padberg W, Grau V.
Monocytic Tissue Transglutaminase in a Rat Model for Reversible Acute Rejection and Chronic Renal Allograft Injury.
Mediators Inflamm. 2015;2015:429653.
Abstract

Zakrzewicz A, Kutlimuratov K, Atanasova S, Zakrzewicz D, Reichert M, Schmitz J, Wilhelm J, Lochnit G, Padberg W, Grau V.
Attenuation of Acute Rat Renal Allograft Rejection by Apolipoprotein E-Mimetic Peptide.
Transplantation. 2015 Feb 25.
Abstract

Beckmann J1, Schubert J, Morhenn HG, Grau V, Schnettler R, Lips KS.
Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis.
Cell Tissue Res. 2014 Nov 25. [Epub ahead of print]
Abstract

Panneck AR1, Rafiq A, Schütz B, Soultanova A, Deckmann K, Chubanov V, Gudermann T, Weihe E, Krasteva-Christ G, Grau V, Del Rey A, Kummer W.
Cholinergic epithelial cell with chemosensory traits in murine thymic medulla.
Cell Tissue Res. 2014 Dec;358(3):737-48. Epub 2014 Oct 10.
Abstract

Körner C, Kuchenbuch T, Pfeil U, Jung K, Padberg W, Kummer W, Mühlfeld C, Grau V.
Low-dose adrenomedullin-2/intermedin(8-47) reduces pulmonary ischemia/reperfusion injury.Peptides. 2014 Oct 5. pii: S0196-9781(14)00291-5
Abstract

Evers A, Atanasova S, Fuchs-Moll G, Petri K, Wilker S, Zakrzewicz A, Hirschburger M, Padberg W, Grau V.
Adaptive and innate immune responses in a rat orthotopic lung transplant model of chronic lung allograft dysfunction.
Transpl Int. 2014 Sep 1
Abstract

Meixner M, Atanasova S, Padberg W, Grau V.
Expression of acetylcholine receptors by experimental rat renal allografts.
Biomed Res Int. 2014;2014:289656, Epub 2014 Jul 9.
Abstract

Holler JP, Schmitz J, Roehrig R, Wilker S, Hecker A, Padberg W, Grau V.
Expression of peptide YY by human blood leukocytes.
Peptides. 2014 Jun 23. pii: S0196-9781(14)00155-7
Abstract

Skwirba M, Zakrzewicz A, Atanasova S, Wilker S, Fuchs-Moll G, Müller D, Padberg W, Grau V.
Expression of nestin after renal transplantation in the rat.
APMIS. 2014 Apr 4
Abstract

Atanasova S, Hirschburger M, Jonigk D, Obert M, Petri K, Evers A, Hecker A, Schmitz J, Kaufmann A, Wilhelm J, Chakraborty T, Warnecke G, Gottlieb J, Padberg W, Grau V.
A relevant experimental model for human bronchiolitis obliterans syndrome.
J Heart Lung Transplant. 2013 Nov;32(11):1131-9. doi: 10.1016/j.healun.2013.07.016 . Epub 2013 Sep 16.
Abstract

Grau V, Fuchs-Moll G, Wilker S, Weimer R, Padberg W.
Proliferation of CD8-positive T cells in blood vessels of rat renal allografts.
Am J Transplant. 2011 Sep;11(9):1979-85. doi: 10.1111/j.1600-6143.2011.03642.x . Epub 2011 Aug 9.
Abstract

Seifart C, Muyal JP, Plagens A, Yildirim AÖ, Kohse K, Grau V, Sandu S, Reinke C, Tschernig T, Vogelmeier C, Fehrenbach H. All-trans retinoic acid results in irregular repair of septa and fails to inhibit proinflammatory macrophages.
Eur Respir J. 2011 Aug;38(2):425-39. Epub 2011 Jan 27.
Abstract

Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V.
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys.
Immunobiology. 2011 Jul;216(7):854-61. Epub 2010 Dec 3.
Abstract

Zakrzewicz A, Wilhelm J, Blöcher S, Wilczynska J, Wilker S, Dietrich H, Weimer R, Padberg W, Grau V.
Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys.
Immunobiology. 2011 May;216(5):613-24. Epub 2010 Sep 24.
Abstract

Ploetz C, Janssen H, Zakrzewicz A, Paddenberg R, Padberg W, Kummer W, Grau V.
Fumarate in the preservation solution aggravates chronic allograft nephropathy.
J Surg Res. 2011 Apr;166(2):306-13. Epub 2009 Jun 27
Abstract

Wilczynska J, Pfeil U, Zakrzewicz A, Dietrich H, Körner C, Hecker A, Wessler I, Padberg W, Kummer W, Grau V.
Acetylcholine and chronic vasculopathy in rat renal allografts.
Transplantation. 2011 Feb 15;91(3):263-70.
Abstract

Zakrzewicz D, Zakrzewicz A, Wilker S, Boedeker RH, Padberg W, Eickelberg O, Grau V.
Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts.
Nephrol Dial Transplant. 2011 Jan;26(1):124-35. Epub 2010 Jul 19.
Abstract

Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB.
Nomenclature of monocytes and dendritic cells in blood.
Blood. 2010 Oct 21;116(16):e74-80. Epub 2010 Jul 13
Abstract

Mikulski Z, Hartmann P, Jositsch G, Zaslona Z, Lips KS, Pfeil U, Kurzen H, Lohmeyer J, Clauss WG, Grau V, Fronius M, Kummer W.
Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration.
Respir Res. 2010 Sep 29;11:133.
Abstract

Holler J, Zakrzewicz A, Garn H, Hirschburger M, Kummer W, Padberg W, Grau V.
Increased expression of epidermal fatty acid-binding protein by alveolar macrophages during acute rejection of rat lungs.
APMIS. 2010 Oct;118(10):791-800. doi: 10.1111/j.1600-0463.2010.02662.x . Epub 2010 Aug 17.
Abstract

Paddenberg  R, Howold N, Hoger C, Janssen H, Grau V, Kummer W.
Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2
Cell Biochem Funct. 2009 Dec;27(8):516-25.
Abstract

Hirschburger M, Zakrzewicz A, Kummer W, Padberg W, Grau V.
Nicotine attenuates macrophage infiltration in rat lung allografts.
J Heart Lung Transplant. 2009 May;28(5):493-500.
Abstract

Hecker A, Mikulski Z, Lips KS, Pfeil U, Zakrzewicz A, Wilker S, Hartmann P, Padberg W, Wessler I, Kummer W, Grau V.
Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts.
J Leukoc Biol. 2009 Jul;86(1):13-22. Epub 2009 Apr 30.
Abstract

Greschus S, Kuchenbuch T, Plötz C, Obert M, Traupe H, Padberg W, Grau V, Hirschburger M.
Monitoring of experimental rat lung transplants by high-resolution flat-panel volumetric computer tomography (fpVCT).
J Invest Surg. 2009 Jan-Feb;22(1):69-75.
Abstract

Hecker A, Kaufmann A, Hecker M, Padberg W, Grau V.
Expression of interleukin-21, interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection.
Immunobiology. 2009;214(1):41-9. Epub 2008 Jun 17.
Abstract

Hirschburger M, Obert M, Traupe H, Kuchenbuch T, Padberg W, Fehrenbach H, Grau V.
Treatment with keratinocyte growth factor does not improve lung allograft survival in the rat.
Langenbecks Arch Surg. 2009 Jan;394(1):133-41. Epub 2008 Feb 19.
Abstract

Holler J, Zakrzewicz A, Kaufmann A, Wilhelm J, Fuchs-Moll G, Dietrich H, Padberg W, Kuncová J, Kummer W, Grau V.
Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation.
J Immunol. 2008 Nov 15;181(10):6906-12.
Abstract

Hirschburger M, Sauer S, Schwandner T, Schief W, Kuchenbuch T, Zoerb C, Janssen H, Grau V, Stertmann W, Rau WS, Padberg W.
Extratumoral spiral fixed wire marking of small pulmonary nodules for thoracoscopic resection.
Thorac Cardiovasc Surg. 2008 Mar;56(2):106-9.
Abstract

Sadovski J, Kuchenbuch T, Ruppert C, Fehrenbach A, Hirschburger M, Padberg W, Günther A, Hohlfeld JM, Fehrenbach H, Grau V.
Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts.
Eur Respir J. 2008 Jan;31(1):21-8. Epub 2007 Oct 10.
Abstract

Chottová Dvoráková M, Wiegand S, Pesta M, Slavíková J, Grau V, Reischig J, Kuncová J, Kummer W.
Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes.
Neuroscience. 2008 Feb 19;151(4):1016-28. Epub 2007 Dec 8
Abstract

Grau V, Fuchs-Moll G, Krasteva G, Hirschburger M, Steiniger B, Padberg W.
Donor B cells in splenic follicles of experimental pulmonary allograft recipients.
Langenbecks Arch Surg. 2008 Mar;393(2):219-26. Epub 2007 Apr 14.
Abstract

Fehrenbach H, Fehrenbach A, Dietzel E, Tschernig T, Krug N, Grau V, Hohlfeld JM.
Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis.
Anat Rec (Hoboken). 2007 Aug;290(8):974-80
Abstract

Grau V, Wilker S, Lips KS, Hartmann P, Rose F, Padberg W, Fehrenbach H, Wessler I, Kummer W.
Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine production.
Int J Biochem Cell Biol. 2007;39(10):1955-63. Epub 2007 May 31.
Abstract

Blöcher S, Wilker S, Sucke J, Pfeil U, Dietrich H, Weimer R, Steger K, Kaufmann A, Hirschburger M, Plötz C, Padberg W, Grau V.
Acute rejection of experimental lung allografts: characterization of intravascular mononuclear leukocytes.
Clin Immunol. 2007 Jul;124(1):98
Abstract

Biallas S, Wilker S, Lips KS, Kummer W, Grando SA, Padberg W, Grau V.
Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts.
Life Sci. 2007 May 30;80(24-25):2286-9. Epub 2007 Feb 1.
Abstract

Lips KS, Lührmann A, Tschernig T, Stoeger T, Alessandrini F, Grau V, Haberberger RV, Koepsell H, Pabst R, Kummer W.
Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse.
Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
Abstract

Grau V, Wilker S, Hartmann P, Lips KS, Grando SA, Padberg W, Fehrenbach H, Kummer W.
Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10.
Life Sci. 2007 May 30;80(24-25):2290-3. Epub 2007 Jan 23
Abstract

Hirschburger M, Greschus S, Kuchenbuch T, Plötz C, Obert M, Traupe H, Padberg W, Grau V.
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans.
J Heart Lung Transplant. 2007 Apr;26(4):390-8.
Abstract

Schmidt A, Sucke J, Fuchs-Moll G, Freitag P, Hirschburger M, Kaufmann A, Garn H, Padberg W, Grau V.
Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ.
J Leukoc Biol. 2007 Jan;81(1):186-94. Epub 2006 Oct 19.
Abstract

Grau V, Wilker S, Hartmann P, Lips KS, Grando SA, Padberg W, Fehrenbach H, Kummer W.
Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10.
Life Sci. 2007 May 30;80(24-25):2290-3. Epub 2007 Jan 23.
Abstract

Hecker A, Lips KS, Pfeil U, Kummer W, Padberg W, Grau V.
Peripheral choline acetyltransferase is expressed by monocytes and upregulated during renal allograft rejection in rats.
J Mol Neurosci. 2006;30(1-2):23-4.
Abstract

Groth M, Helbig T, Grau V, Kummer W, Haberberger RV.
Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels.
Respir Res. 2006 Jul 1;7:96.
Abstract

Groth M, Helbig T, Grau V, Kummer W, Haberberger RV.
Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels.
Respir Res. 2006 Jul 1;7:96.
Abstract

Dvoráková MC, Pfeil U, Kuncová J, Svíglerová J, Galvis G, Krasteva G, König P, Grau V, Slavíková J, Kummer W.
Down-regulation of vasoactive intestinal peptide and altered expression of its receptors in rat diabetic cardiomyopathy.
Cell Tissue Res. 2006 Mar;323(3):383-93. Epub 2005 Dec 13
Abstract

Grau V, Garn H, Holler J, Rose F, Blöcher S, Hirschburger M, Fehrenbach H, Padberg W.
Epidermal fatty acid-binding protein is increased in rat lungs following in vivo treatment with keratinocyte growth factor.
Int J Biochem Cell Biol. 2006 Feb;38(2):279-87. Epub 2005 Oct 3.
Abstract

Kummer W, Stommel C, Grau V.
MHC class II antigen-expressing cells in cardiac ganglia of the rat.
Cell Tissue Res. 319, 37-48 (2005)
Abstract

Stehling O, Grau V, Celik I, Scriba A, Steiniger B:
Monocyte cytotoxicity during acute kidney graft rejection in rats.
Int Immunol 16:101-110 (2004)
Abstract

Schachtrup C, Scholzen TE, Grau V, Luger TA, Sorg C, Spener F, Kerkhoff C:
L-FABP is exclusively expressed in alveolar macrophages  independent expression.
Int Jgwithin the myeloid lineage; Evidence for a PPAR- Biochem Cell Biol 36:2052-2063 (2004)
Abstract