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Forschung/Research

Recent Publications:

 

Filatova A, Seidel S, Böğürcü N, Gräf S, Garvalov BK, Acker T. Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma. Cancer Res. 2016; 76(19):5845-5856. PMID: 27488520

Depner C, Zum Buttel H, Böğürcü N, Cuesta AM, Aburto MR, Seidel S, Finkelmeier F, Foss F, Hofmann J, Kaulich K, Barbus S, Segarra M, Reifenberger G, Garvalov BK, Acker T, Acker-Palmer A. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun. 2016; 7:12329. doi: 10.1038/ncomms12329. PMID: 27470974

Garvalov BK, Acker T. Implications of Oxygen Homeostasis for Tumor Biology and Treatment. Adv Exp Med Biol. 2016; 903:169-85. doi: 10.1007/978-1-4899-7678-9_12. PMID:  27343096

Kolodziej MA, Weischer C, Reinges MH, Uhl E, Weigand MA, Schwarm FP, Schänzer A, Acker T, Quint K, Uhle F, Stein M. NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated Tumors. Anticancer Res. 2016; 36(3):887-97. PMID: 26976975

Droby A, Yuen KS, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R. An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms. Magn Reson Med. 2016 Mar 7. doi: 10.1002/mrm.26196. PMID: 26947146

Schwarm FP, Uhle F, Schänzer A, Acker T, Stein M, Reinges MH, Weischer C, Weigand MA, Uhl E, Kolodziej MA. High-mobility group AT-hook protein 2 expression and its prognostic significance in MGMT methylated and unmethylated glioblastoma. Int J Oncol. 2016; 48(4):1485-92. doi: 10.3892/ijo.2016.3397. PMID: 26892260

Acker H, Schmidt-Rathjens C, Acker T, Fandrey J, Ehleben W. Acupuncture-brain interactions as hypothesized by mood scale recordings. Med Hypotheses. 2015 Sep;85(3):371-9. doi: 10.1016/j.mehy.2015.05.013. PMID: 26025590

Thomas M, Fischer J, Andreas S, Kortsik C, Grah C, Serke M, von Eiff M, Witt C, Kollmeier J, Müller E, Schenk M, Schröder M, Villalobos M, Reinmuth N, Penzel R, Schnabel P, Acker T, Reuss A, Wolf M; ABC-Lung Cancer Group. Erlotinib and bevacizumab versus cisplatin, gemcitabine and bevacizumab in unselected nonsquamous nonsmall cell lung cancer. Eur Respir J. 2015 Jul;46(1):219-29. doi: 10.1183/09031936.00229014. PMID: 25792638

Droby A, Lukas C, Schänzer A, Spiwoks-Becker I, Giorgio A, Gold R, De Stefano N, Kugel H, Deppe M, Wiendl H, Meuth SG, Acker T, Zipp F, Deichmann R. A human post-mortem brain model for the standardization of multi-centre MRI studies. Neuroimage. 2015 Apr 15;110:11-21. doi: 10.1016/j.neuroimage.2015.01.028. PMID: 25595502

Seidel S, Garvalov BK, Acker T. Isolation and culture of primary glioblastoma cells from human tumor specimens. Methods Mol Biol. 2015;1235:263-75. doi: 10.1007/978-1-4939-1785-3_19. PMID: 25388399

Schänzer A, Kimmich C, Röcken C, Haverkamp T, Weidner I, Acker T, Krämer HH. A woman with a rare p.Glu74Gly transthyretin mutation presenting exclusively with a rapidly progressive neuropathy: a case report. J Med Case Rep. 2014 Dec 4;8(1):403. doi: 10.1186/1752-1947-8-403. PMID: 25471118 

Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun. 2014 Nov 25;5:5582. doi: 10.1038/ncomms6582.PMID: 25420773

Garvalov BK, Foss F, Henze AT, Bethani I, Gräf-Höchst S, Singh D, Filatova A, Dopeso H, Seidel S, Damm M, Acker-Palmer A, Acker T. PHD3 regulates EGFR internalization and signalling in tumours. Nat Commun. 2014 Nov 25;5:5577. doi: 10.1038/ncomms6577. PMID: 25420589 

Schänzer A, Döring B, Ondrouschek M, Goos S, Garvalov BK, Geyer J, Acker T, Neubauer B, Hahn A. Stress-induced upregulation of SLC19A3 is impaired in biotin-thiamine-responsive basal ganglia disease. Brain Pathol. 2014 Apr;24(3):270-9. PMID: 24372704

Heim S, Beschorner R, Mittelbronn M, Keyvani K, Riemenschneider MJ, Vajtai I, Hartmann C, Acker T, Blümcke I, Paulus W, Hasselblatt M. Increased mitotic and proliferative activity are associated with worse prognosis in papillary tumors of the pineal region. Am J Surg Pathol. 2014 Jan;38(1):106-10. PMID: 24121176

Stellzig J, Chariot A, Shostak K, Ismail Göktuna S, Renner F, Acker T, Pagenstecher A, Schmitz ML. Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways. Oncogenesis. 2013 Nov 11;2:e79. PMID: 24217713

Fischer S, Gesierich S, Griemert B, Schänzer A, Acker T, Augustin HG, Olsson AK, Preissner KT. Extracellular RNA liberates tumor necrosis factor-α to promote tumor cell trafficking and progression. Cancer Res. 2013 Aug 15;73(16):5080-9. PMID: 23774209

Dietrich S, Hüllein J, Hundemer M, Lehners N, Jethwa A, Capper D, Acker T, Garvalov BK, Andrulis M, Blume C, Schulte C, Mandel T, Meissner J, Fröhling S, von Kalle C, Glimm H, Ho AD, Zenz T. Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia. 3. J Clin Oncol. 2013 Jul 1;31(19):e300-3. doi: 10.1200/JCO.2012.45.9495. PMID: 23690412

Berghoff M, Schänzer A, Hildebrandt GC, Dassinger B, Klappstein G, Kaps M, Gizewski ER, Acker T, Grams A. Development of progressive multifocal leukoencephalopathy in a patient with non-Hodgkin lymphoma 13 years after treatment with cladribine. Leuk Lymphoma. 2013 Jun;54(6):1340-2 PMID: 23098217

Filatova A, Acker T, Garvalov BK. The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment. Biochim Biophys Acta. 2013 Feb;1830(2):2496-508. PMID: 23079585 

Garvalov BK. Sexism: Measure journal objectivity. Nature. 2013 Jan 17;493(7432):305. doi: 10.1038/493305a. PMID: 23325203

Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V. LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Brain Pathol. 2013 Jan;23(1):60-72. PMID: 22805276

Preusser M, Hassler M, Birner P, Rudas M, Acker T, Plate KH, Widhalm G, Knosp E, Breitschopf H, Berger J, Marosi C. Microvascularization and expression of VEGF and its receptors in recurring meningiomas: pathobiological data in favor of anti-angiogenic therapy approaches. Clin Neuropathol. 2012 Sep-Oct;31(5):352-60. PMID: 22541785

Schänzer A, Rau I, Kress W, Köhler A, Neubauer B, Hahn A. Duchenne muscular dystrophy in a 4-year-old girl due to heterozygous frame shift deletion of the dystrophin gene and skewed X-inactivation. Klin Padiatr. 2012 Jul;224(4):256-8. PMID: 22549471

Azoitei N, Kleger A, Schoo N, Thal DR, Brunner C, Pusapati GV, Filatova A, Genze F, Möller P, Acker T, Kuefer R, Van Lint J, Baust H, Adler G, Seufferlein T. Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation. Neuro Oncol. 2011 Jul;13(7):710-24. PMID: 21727210

Garvalov BK, Acker T. Cancer stem cells: a new framework for the design of tumor therapies. J Mol Med. 2011 Feb;89(2):95-107. PMID: 20890588

Nedelmann M, Ritschel N, Doenges S, Langheinrich AC, Acker T, Reuter P, Yeniguen M, Pukropski J, Kaps M, Mueller C, Bachmann G, Gerriets T. Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2010 Oct;30(10):1712-20. PMID: 20531462

Henze AT, Acker T. Feedback regulators of hypoxia-inducible factors and their role in cancer biology. Cell Cycle 2010; 9(14):2749-63. PMID: 20603601

Sawamiphak S, Seidel S, Essmann CL, Wilkinson GA, Pitulescu ME, Acker T*, Acker-Palmer A*. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 2010; 465(7297):487-91.
* These authors contributed equally to this work.
PMID: 20445540

Seidel S, Garvalov BK, Wirta V, von Stechow L, Schänzer A, Meletis K, Wolter M, Sommerlad D, Henze AT, Nistér M, Reifenberger G, Lundeberg J, Frisén J, Acker T.  A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2alpha. Brain. 2010; 133:983-95. 
PMID: 20375133
Free-access link (PDF): http://brain.oxfordjournals.org/cgi/reprint/awq042?ijkey=cdSu4fHTmmlrVsu&keytype=ref

Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res. 2010; 70(1):357-66. PMID: 20028863