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PD Dr. Behrooz H. Yousefi

Leiter der Radiopharmazie

Tel.: 06421/58-65806
Fax: 06421/58-62899

yousefi@med.uni-marburg.de

T Grimmer; K Shi, …, BH Yousefi 18F-FIBT may expand PET for β-Amyloid Imaging in Neurodegenerative Diseases Mol Psychiatry 2018; https://doi.org/10.1038/s41380-018-0203-5. 

M Brendel*, BH Yousefi*, T Blume,… A Rominger Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology Front Aging Neurosci. 2018; 10: 174. 

Robu S, Schmidt A, Eiber M, Schottelius M, Günther T, Yousefi BH, Schwaiger M and Wester HJ Synthesis and preclinical evaluation of novel 18F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with 18F-DCFPyl and 18F-PSMA-1007 EJNMMI Research 2018 8:30, https://doi.org/10.1186/s13550-018-0382-8 

Lee M, Minaskan N, Wiedemann T, Irmler M, Beckers J, Yousefi BH, et al. Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo. Endocr Relat Cancer. 2017;24(1):1-15. 

Tahmasian M, Shao JM, Meng C, Grimmer T, Diehl-Schmid J, Yousefi BH, et al. Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study. Journal of Nuclear Medicine. 2016;57(3):410-5. 

Yousefi BH, von Reutern B, Scherubl D, Manook A, Schwaiger M, Grimmer T, et al. FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice. EJNMMI Res. 2015;5. 

Yousefi BH*, Manook A*, Grimmer T, Arzberger T, von Reutern B, Henriksen G, et al. Characterization and First Human Investigation of FIBT, a Novel Fluorinated A beta Plaque Neuroimaging PET Radioligand. ACS chemical neuroscience. 2015;6(3):428-37. 

Ortner M, Kurz A, Alexopoulos P, … Yousefi BH, Grimmer T Small Vessel Disease, but Neither Amyloid Load nor Metabolic Deficit, Is Dependent on Age at Onset in Alzheimer's Disease. Biological psychiatry. 2015;77(8):704-10. 

Klupp E, Grimmer T, Tahmasian M, Sorg C, Yakushev I, Yousefi BH, et al. Prefrontal hypometabolism in Alzheimer disease is related to longitudinal amyloid accumulation in remote brain regions. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2015;56(3):399-404. 

Higuchi T*, Yousefi BH*, Reder S, Beschorner M, Laitinen I, Yu M, et al. Myocardial Kinetics of a Novel [F-18]-Labeled Sympathetic Nerve PET Tracer LMI1195 in the Isolated Perfused Rabbit Heart. Jacc-Cardiovasc Imag. 2015;8(10):1229-31. 

Klupp E, Forster S, Grimmer T, Tahmasian M, Yakushev I, Sorg C, Yousefi BH, and Drzezga A In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions. Brain Connectivity. 2014;4(5):371-83. 

Grimmer T, Goldhardt O, Guo LH, Yousefi BH, Forster S, Drzezga A, et al. LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo. NeuroImage Clinical. 2014;4:411-6. 

von Reutern B, Grunecker B, Yousefi BH, Henriksen G, Czisch M, Drzezga A. Voxel-based analysis of amyloid-burden measured with [(11)C]PiB PET in a double transgenic mouse model of Alzheimer's disease. Mol Imaging Biol. 2013;15(5):576-84. 

Higuchi T, Yousefi BH, Kaiser F, Gartner F, Rischpler C, Reder S, et al. Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2013;54(7):1142-6. 

Gaertner FC, Wiedemann T, Yousefi BH, Lee M, Repokis I, Higuchi T, et al. Preclinical evaluation of 18F-LMI1195 for in vivo imaging of pheochromocytoma in the MENX tumor model. Journal of nuclear medicine 2013;54(12):2111-7. 

Bahrami K, Khodaei MM, Naali F, Yousefi BH. Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH-). Tetrahedron Lett. 2013;54(39):5293-8. 

Yousefi BH, Manook A, von Reutern B, Schwaiger M, Drzezga A, Wester H-J, et al. Development of an improved radioiodinated 2-phenylimidazo[1,2-a]pyridine for non-invasive imaging of amyloid plaques. MedChemComm. 2012;3(7):775-9. 

Manook A, Yousefi BH, Willuweit A, Platzer S, Reder S, Voss A, et al. Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease. PLoS One. 2012;7(3):e31310. 

Grimmer T, Faust M, Auer F, Alexopoulos P, Forstl H, Henriksen G, Yousefi BH et al. White matter hyperintensities predict amyloid increase in Alzheimer's disease. Neurobiology of aging. 2012;33(12):2766-73. 

Grimmer T, Alexopoulos P, Tsolakidou A, Guo LH, Henriksen G, Yousefi BH, et al. Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease. TheScientificWorldJournal. 2012;2012:712048. 

Forster S, Yousefi BH, Wester HJ, Klupp E, Rominger A, Forstl H, et al. Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2012;39(12):1927-36. 

Forster S, Grimmer T, Miederer I, Henriksen G, Yousefi BH, Graner P, et al. Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay. Biological psychiatry. 2012;71(9):792-7. 

Bahrami K, Khodaei MM, Shakibaian V, Khaledian D, Yousefi BH. TiCl4-promoted desulfurization of thiocarbonyls and oxidation of sulfides in the presence of H2O2. J Sulfur Chem. 2012;33(2):155-63. 

Yousefi BH, Manook A, Drzezga A, von Reutern B, Schwaiger M, Wester HJ, et al. Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging beta-amyloid plaques in Alzheimer's disease. Journal of medicinal chemistry. 2011;54(4):949-56. 

Yousefi BH, Drzezga A, von Reutern B, Manook A, Schwaiger M, Wester HJ, et al. A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of beta-Amyloid Plaques. ACS medicinal chemistry letters. 2011;2(9):673-7. 

Jouyban A, Shayanfar A, Panahi-Azar V, Soleymani J, Yousefi BH, Acree WE, Jr., et al. Solubility prediction of drugs in mixed solvents using partial solubility parameters. J Pharm Sci. 2011;100(10):4368-82. 

Bahrami K, Khodaei MM, Yousefi BH, Arabi MS. TMSCl-promoted selective oxidation of sulfides to sulfoxides with hydrogen peroxide (vol 51, pg 6939, 2010). Tetrahedron Lett. 2011;52(16):2002-3. 

Grimmer T, Tholen S, Yousefi BH, Alexopoulos P, Forschler A, Forstl H, et al. Progression of cerebral amyloid load is associated with the apolipoprotein E epsilon4 genotype in Alzheimer's disease. Biological psychiatry. 2010;68(10):879-84. 

Marton J, Schoultz BW, Hjornevik T, Drzezga A, Yousefi BH, Wester HJ, et al. Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO. Journal of medicinal chemistry. 2009;52(18):5586-9. 

Henriksen G, Yousefi BH, Drzezga A, Wester HJ. Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography. European journal of nuclear medicine and molecular imaging. 2008;35 Suppl 1:S75-81. 

Abdollahi-Alibeik M, Mohammadpoor-Baltork I, Zaghaghi Z, Yousefi BH. Efficient synthesis of 1,5-benzodiazepines catalyzed by silica supported 12-tungstophosphoric acid. Catal Commun. 2008;9(15):2496-502. 

Moghadam M, Mohammadpoor-Baltork I, Mirkhani V, Tangestaninejad S, Abdollahi-Alibeik M, Yousefi BH, et al. Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation. Monatsh Chem. 2007;138(6):579-83. 

Henriksen G, Hauser AI, Westwell AD, Yousefi BH, Schwaiger M, Drzezga A, et al. Metabolically stabilized benzothiazoles for imaging of amyloid plaques. Journal of medicinal chemistry. 2007;50(6):1087-9. 

Yousefi BH, Jordis U. Hexestrol bis[2-(diethylamino)ethyl] ether dihydrochloride. Molbank. 2006:M511. 

Knesl P, Yousefi BH, Mereiter K, Jordis U. Synthesis of (-)- and (+)-8-fluoro-galanthamine. Tetrahedron Lett. 2006;47(32):5701-3. 

Gorobets NY, Yousefi BH, Belaj F, Kappe CO. Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries. Tetrahedron. 2004;60(39):8633-44. 

Stadler A, Yousefi BH, Dallinger D, Walla P, Van Der Eycken E, Kaval N, et al. Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors. Org Process Res Dev. 2003;7(5):707-16. 

Jouyban A, Yousefi BH. A quantitative structure property relationship study of electrophoretic mobility of analytes in capillary zone electrophoresis. Computational biology and chemistry. 2003;27(3):297-303. 

Fakhri SA, Yousefi BH. Synthesis and characterization of 8-hydroxy-5,8,9,10-tetrahydro-6H-benzocycloocten-7-one, 5,6,9,10-tetrahydrobenzocyclo-octene-7,8-dione and 6,7,10,11-tetrahydrobenzocycloocta-[b]quinoxaline. Acta Chim Slov. 2000;47(3):317-26. 

Fakhri SA, Yousefi BH. Efficient synthesis and theoretical study of siloxy-benzocyclooctenes: 7,8-bis-trimethylsilanyloxy-5,6,9,10-tetrahydro-benzocyclooctene and 6,9-dimethyl-7,8-bis-trimethylsilanyloxy-5,6,9,10,-tetrahydro-benzocyclooctene-6,9-dicarboxylic acid diethyl ester. Tetrahedron. 

Book chapters 

Kappe CO, Stadler A, Dallinger D, Strohmeier G, Perez R, Zbruyev OI,…, Yousefi BH et al. Adventures in microwave-assisted organic synthesis: Contributions from the Kappe Laboratory 2000-2005. NATO Sci Ser, II. 2008;246 (New Methodologies and Techniques for a Sustainable Organic Chemistry):225-51. 

Yousefi BH, Wester HJ, 2015, “Development of 18F-labeled compounds for imaging of Aβ plaques by means of PET“, Fluorinated Pharmaceuticals: Advances in Medicinal Chemistry, Westwell AD (editor); ISBN: 978-1-910419-00-7 © 2015 Future Science Ltd 

Patents 

1. EP14175824.0 and PCT/EP2015/065241. July 2015 Compounds binding to neuropathological aggregates Wester HJ and Yousefi BH 

2. WO 2015004029 A1, Jan 15, 2015, 18F-labeling of aromatic and heteroaromatic molecules containing unprotected carboxylic acid groups using cryptate mediated no-carrier-added nucleophilic fluorination Yousefi BH, Bollinger M, Kessler H, Wester H-J 

3. WO2010092111A2, EP2218464 A1, PCT/EP2010/051704, DE112010000820 T5, 2010, Compounds for non-invasive measurement of aggregates of amyloid peptides; Henriksen G, Yousefi BH, Wester H-J 

4. EP1944281A1. 2008. Preparation of 18F-labeled aniline derivatives for use as diagnostic agents in non-invasive imaging; Henriksen G, Hooshyar Yousefi B, Wester H-J 

5. EP20070100290, 01/09/2007, 18F-labeled compounds, method for the preparation and use thereof; Henriksen, G., Yousefi, B. H., Wester H-J

Publikationen

T Grimmer; K Shi, …, BH Yousefi 18F-FIBT may expand PET for β-Amyloid Imaging in Neurodegenerative Diseases Mol Psychiatry 2018; https://doi.org/10.1038/s41380-018-0203-5. 

M Brendel*, BH Yousefi*, T Blume,… A Rominger Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology Front Aging Neurosci. 2018; 10: 174. 

Robu S, Schmidt A, Eiber M, Schottelius M, Günther T, Yousefi BH, Schwaiger M and Wester HJ Synthesis and preclinical evaluation of novel 18F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with 18F-DCFPyl and 18F-PSMA-1007 EJNMMI Research 2018 8:30, https://doi.org/10.1186/s13550-018-0382-8 

Lee M, Minaskan N, Wiedemann T, Irmler M, Beckers J, Yousefi BH, et al. Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo. Endocr Relat Cancer. 2017;24(1):1-15. 

Tahmasian M, Shao JM, Meng C, Grimmer T, Diehl-Schmid J, Yousefi BH, et al. Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study. Journal of Nuclear Medicine. 2016;57(3):410-5. 

Yousefi BH, von Reutern B, Scherubl D, Manook A, Schwaiger M, Grimmer T, et al. FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice. EJNMMI Res. 2015;5. 

Yousefi BH*, Manook A*, Grimmer T, Arzberger T, von Reutern B, Henriksen G, et al. Characterization and First Human Investigation of FIBT, a Novel Fluorinated A beta Plaque Neuroimaging PET Radioligand. ACS chemical neuroscience. 2015;6(3):428-37. 

Ortner M, Kurz A, Alexopoulos P, … Yousefi BH, Grimmer T Small Vessel Disease, but Neither Amyloid Load nor Metabolic Deficit, Is Dependent on Age at Onset in Alzheimer's Disease. Biological psychiatry. 2015;77(8):704-10. 

Klupp E, Grimmer T, Tahmasian M, Sorg C, Yakushev I, Yousefi BH, et al. Prefrontal hypometabolism in Alzheimer disease is related to longitudinal amyloid accumulation in remote brain regions. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2015;56(3):399-404. 

Higuchi T*, Yousefi BH*, Reder S, Beschorner M, Laitinen I, Yu M, et al. Myocardial Kinetics of a Novel [F-18]-Labeled Sympathetic Nerve PET Tracer LMI1195 in the Isolated Perfused Rabbit Heart. Jacc-Cardiovasc Imag. 2015;8(10):1229-31. 

Klupp E, Forster S, Grimmer T, Tahmasian M, Yakushev I, Sorg C, Yousefi BH, and Drzezga A In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions. Brain Connectivity. 2014;4(5):371-83. 

Grimmer T, Goldhardt O, Guo LH, Yousefi BH, Forster S, Drzezga A, et al. LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo. NeuroImage Clinical. 2014;4:411-6. 

von Reutern B, Grunecker B, Yousefi BH, Henriksen G, Czisch M, Drzezga A. Voxel-based analysis of amyloid-burden measured with [(11)C]PiB PET in a double transgenic mouse model of Alzheimer's disease. Mol Imaging Biol. 2013;15(5):576-84. 

Higuchi T, Yousefi BH, Kaiser F, Gartner F, Rischpler C, Reder S, et al. Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2013;54(7):1142-6. 

Gaertner FC, Wiedemann T, Yousefi BH, Lee M, Repokis I, Higuchi T, et al. Preclinical evaluation of 18F-LMI1195 for in vivo imaging of pheochromocytoma in the MENX tumor model. Journal of nuclear medicine 2013;54(12):2111-7. 

Bahrami K, Khodaei MM, Naali F, Yousefi BH. Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH-). Tetrahedron Lett. 2013;54(39):5293-8. 

Yousefi BH, Manook A, von Reutern B, Schwaiger M, Drzezga A, Wester H-J, et al. Development of an improved radioiodinated 2-phenylimidazo[1,2-a]pyridine for non-invasive imaging of amyloid plaques. MedChemComm. 2012;3(7):775-9. 

Manook A, Yousefi BH, Willuweit A, Platzer S, Reder S, Voss A, et al. Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease. PLoS One. 2012;7(3):e31310. 

Grimmer T, Faust M, Auer F, Alexopoulos P, Forstl H, Henriksen G, Yousefi BH et al. White matter hyperintensities predict amyloid increase in Alzheimer's disease. Neurobiology of aging. 2012;33(12):2766-73. 

Grimmer T, Alexopoulos P, Tsolakidou A, Guo LH, Henriksen G, Yousefi BH, et al. Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease. TheScientificWorldJournal. 2012;2012:712048. 

Forster S, Yousefi BH, Wester HJ, Klupp E, Rominger A, Forstl H, et al. Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2012;39(12):1927-36. 

Forster S, Grimmer T, Miederer I, Henriksen G, Yousefi BH, Graner P, et al. Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay. Biological psychiatry. 2012;71(9):792-7. 

Bahrami K, Khodaei MM, Shakibaian V, Khaledian D, Yousefi BH. TiCl4-promoted desulfurization of thiocarbonyls and oxidation of sulfides in the presence of H2O2. J Sulfur Chem. 2012;33(2):155-63. 

Yousefi BH, Manook A, Drzezga A, von Reutern B, Schwaiger M, Wester HJ, et al. Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging beta-amyloid plaques in Alzheimer's disease. Journal of medicinal chemistry. 2011;54(4):949-56. 

Yousefi BH, Drzezga A, von Reutern B, Manook A, Schwaiger M, Wester HJ, et al. A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of beta-Amyloid Plaques. ACS medicinal chemistry letters. 2011;2(9):673-7. 

Jouyban A, Shayanfar A, Panahi-Azar V, Soleymani J, Yousefi BH, Acree WE, Jr., et al. Solubility prediction of drugs in mixed solvents using partial solubility parameters. J Pharm Sci. 2011;100(10):4368-82. 

Bahrami K, Khodaei MM, Yousefi BH, Arabi MS. TMSCl-promoted selective oxidation of sulfides to sulfoxides with hydrogen peroxide (vol 51, pg 6939, 2010). Tetrahedron Lett. 2011;52(16):2002-3. 

Grimmer T, Tholen S, Yousefi BH, Alexopoulos P, Forschler A, Forstl H, et al. Progression of cerebral amyloid load is associated with the apolipoprotein E epsilon4 genotype in Alzheimer's disease. Biological psychiatry. 2010;68(10):879-84. 

Marton J, Schoultz BW, Hjornevik T, Drzezga A, Yousefi BH, Wester HJ, et al. Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO. Journal of medicinal chemistry. 2009;52(18):5586-9. 

Henriksen G, Yousefi BH, Drzezga A, Wester HJ. Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography. European journal of nuclear medicine and molecular imaging. 2008;35 Suppl 1:S75-81. 

Abdollahi-Alibeik M, Mohammadpoor-Baltork I, Zaghaghi Z, Yousefi BH. Efficient synthesis of 1,5-benzodiazepines catalyzed by silica supported 12-tungstophosphoric acid. Catal Commun. 2008;9(15):2496-502. 

Moghadam M, Mohammadpoor-Baltork I, Mirkhani V, Tangestaninejad S, Abdollahi-Alibeik M, Yousefi BH, et al. Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation. Monatsh Chem. 2007;138(6):579-83. 

Henriksen G, Hauser AI, Westwell AD, Yousefi BH, Schwaiger M, Drzezga A, et al. Metabolically stabilized benzothiazoles for imaging of amyloid plaques. Journal of medicinal chemistry. 2007;50(6):1087-9. 

Yousefi BH, Jordis U. Hexestrol bis[2-(diethylamino)ethyl] ether dihydrochloride. Molbank. 2006:M511. 

Knesl P, Yousefi BH, Mereiter K, Jordis U. Synthesis of (-)- and (+)-8-fluoro-galanthamine. Tetrahedron Lett. 2006;47(32):5701-3. 

Gorobets NY, Yousefi BH, Belaj F, Kappe CO. Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries. Tetrahedron. 2004;60(39):8633-44. 

Stadler A, Yousefi BH, Dallinger D, Walla P, Van Der Eycken E, Kaval N, et al. Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors. Org Process Res Dev. 2003;7(5):707-16. 

Jouyban A, Yousefi BH. A quantitative structure property relationship study of electrophoretic mobility of analytes in capillary zone electrophoresis. Computational biology and chemistry. 2003;27(3):297-303. 

Fakhri SA, Yousefi BH. Synthesis and characterization of 8-hydroxy-5,8,9,10-tetrahydro-6H-benzocycloocten-7-one, 5,6,9,10-tetrahydrobenzocyclo-octene-7,8-dione and 6,7,10,11-tetrahydrobenzocycloocta-[b]quinoxaline. Acta Chim Slov. 2000;47(3):317-26. 

Fakhri SA, Yousefi BH. Efficient synthesis and theoretical study of siloxy-benzocyclooctenes: 7,8-bis-trimethylsilanyloxy-5,6,9,10-tetrahydro-benzocyclooctene and 6,9-dimethyl-7,8-bis-trimethylsilanyloxy-5,6,9,10,-tetrahydro-benzocyclooctene-6,9-dicarboxylic acid diethyl ester. Tetrahedron. 

Book chapters 

Kappe CO, Stadler A, Dallinger D, Strohmeier G, Perez R, Zbruyev OI,…, Yousefi BH et al. Adventures in microwave-assisted organic synthesis: Contributions from the Kappe Laboratory 2000-2005. NATO Sci Ser, II. 2008;246 (New Methodologies and Techniques for a Sustainable Organic Chemistry):225-51. 

Yousefi BH, Wester HJ, 2015, “Development of 18F-labeled compounds for imaging of Aβ plaques by means of PET“, Fluorinated Pharmaceuticals: Advances in Medicinal Chemistry, Westwell AD (editor); ISBN: 978-1-910419-00-7 © 2015 Future Science Ltd 

Patents 

1. EP14175824.0 and PCT/EP2015/065241. July 2015 Compounds binding to neuropathological aggregates Wester HJ and Yousefi BH 

2. WO 2015004029 A1, Jan 15, 2015, 18F-labeling of aromatic and heteroaromatic molecules containing unprotected carboxylic acid groups using cryptate mediated no-carrier-added nucleophilic fluorination Yousefi BH, Bollinger M, Kessler H, Wester H-J 

3. WO2010092111A2, EP2218464 A1, PCT/EP2010/051704, DE112010000820 T5, 2010, Compounds for non-invasive measurement of aggregates of amyloid peptides; Henriksen G, Yousefi BH, Wester H-J 

4. EP1944281A1. 2008. Preparation of 18F-labeled aniline derivatives for use as diagnostic agents in non-invasive imaging; Henriksen G, Hooshyar Yousefi B, Wester H-J 

5. EP20070100290, 01/09/2007, 18F-labeled compounds, method for the preparation and use thereof; Henriksen, G., Yousefi, B. H., Wester H-J