Ein Unternehmen der RHÖN-KLINIKUM AG

Prof. Dr. Katrin Susanne Lips

Leiterin Tel.: 0641/99-30580 Fax: 0641/99-30589 Katrin.S.Lips@chiru.med.uni-giessen.de

Originalarbeiten:

Hemm, F.; Fijak, M.; Belikan, J.; Kampschulte, M.; El Khassawna, T.; Pilatz, A.; Heiss, C.; Lips, K.S. Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis. Int J Mol Sci. 2021 Jul 23;22(15):7858. doi: 10.3390/ijms22157858.

Spreda, M.; Hauptmann, N.; Lehner, V.; Biehl, C.; Liefeith, K.; Lips, K.S. Porous 3D scaffolds enhance MSC vitalitiy and reduce osteoclast activity. Molecules. 2021 Oct 16;26(20):6258. doi: 10.3390/molecules26206258.

Loy, T.L.; Vehlow, D.; Kauschke, V.; Müller, M.; Heiss, C.; Lips, K.S. Effects of BDNF and PEC Nanoparticles on Osteocytes. Molecules. 2020 Sep 10;25(18):E4151. doi: 10.3390/molecules25184151

Fölsch, C.; Dharma, J.; Fonseca Ulloa, C.A.; Lips, K.S.; Rickert, M.; Pruss, A.; Jahnke A. Influence of thermodisinfection on microstructure of human femoral heads: duration of heat exposition and compressive strength. Cell Tissue Bank. 2020 Sep;21(3):457-468. doi: 10.1007/s10561-020-09832-5. Epub 2020 Apr 20.

Alagboso, F.I.; Budak, M.; Sommer, U.; Ray, S.; Kaiser, A.; Kampschulte, M.; Henss, A.; Dürselen, L.; Biehl, C.; Lips, K.S.; Heiss, C.; Thormann, U.; Alt, V. Establishment of a clinically relevant large animal model to assess the healing of metaphyseal bone. Eur Cell Mater. 2019 Jun 20;37:444-466. doi: 10.22203/eCM.v037a27.

Kauschke, V.; Hessland, F.M.; Vehlow, D.; Müller, M.; Heiss, C.; Lips, K.S. High Concentrations of Polyelectrolyte Complex Nanoparticles Decrease Activity of Osteoclasts. Molecules. 2019 Jun 25;24(12). pii: E2346. doi: 10.3390/molecules24122346.

Baumann, L.; Kauschke, V.; Vikman, A.; Dürselen, L.; Krasteva-Christ, G.; Kampschulte, M.; Heiss, C.; Yee, K.T.; Vetter, D.E.; Lips, K.S. Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure. Bone. 2019 Mar;120:285-296. doi: 10.1016/j.bone.2018.11.003. Epub 2018 Nov 7.

Brunotte, M.; Rupp, M.; Stötzel, S.; Sommer, U.; Mohammed, W.; Thormann, U.; Heiss, C.; Lips, K.S.; Domann, E.; Alt, V. A new small animal model for simulating a two-stage-revision procedure in implant-related methicillin-resistant Staphylococcus aureus bone infection. Injury. 2019 Nov;50(11):1921-1928. doi: 10.1016/j.injury.2019.08.017. Epub 2019 Aug 15

Kauschke, V.; Schneider, M.; Jauch, A.; Schumacher, M.; Kampschulte, M.; Rohnke, M.; Henss, A.; Bamberg, C.; Trinkaus, K.; Gelinsky, M.; Heiss, C.; Lips, K.S. Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model. Int J Mol Sci. 2018 Nov 9;19(11). pii: E3531. doi: 10.3390/ijms19113531.

Franke, J.; Brobeil, A.; Lips, K.S.; Gattenloehner, S.; Franke, A.P.; Hohendorff, B.; Alt, V.; Schnettler, R. Importance of Mechanoreceptors and Other Neural Structures Within the Anterior Intermeniscal Ligament in the Etiology of Anterior Knee Pain After Tibial Nailing. J Orthop Trauma. 2018 Oct;32(10):526-533. doi: 10.1097/BOT.0000000000001258.

Al Khasawnah, Q.; Hassan, F.; Malhan, D.; Engelhardt, M.; Daghma, D.E.S.; Obidat, D.; Lips, K.S.; El Khassawna, T.; Heiss, C.  Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste. Biomed Res Int. 2018 Feb 12;2018:8198795. doi: 10.1155/2018/8198795. eCollection 2018.

Henss, A.; Otto, S.K.; Schaepe, K.; Pauksch, L.; Lips, K.S.; Rohnke, M. High resolution imaging and 3D analysis of Ag nanoparticles in cells with ToF-SIMS and delayed extraction. Biointerphases. 2018 Feb 28;13(3):03B410. doi: 10.1116/1.5015957.

Kauschke, V.; Gebert, A.; Calin, M.; Eckert, J.; Scheich, S.; Heiss, C.; Lips, K.S. Effects of new beta-type Ti-40Nb implant materials, brain-derived neurotrophic factor, acetylcholine and nicotine on human mesenchymal stem cells of osteoporotic and non osteoporotic donors. PLoS One. 2018 Feb 28;13(2):e0193468. doi: 10.1371/journal.pone.0193468. eCollection 2018.

Mannala, G.K.; Koettnitz, J.; Mohamed, W.; Sommer, U.; Lips, K.S.; Spröer, C.; Bunk, B.; Overmann, J.; Hain, T.; Heiss, C.; Domann, E.; Alt, V. Whole-genome comparison of high and low virulent Staphylococcus aureus isolates inducing implant-associated bone infections. Int J Med Microbiol. 2018 Apr 25. pii: S1438-4221(17)30603-3. doi: 10.1016/j.ijmm.2018.04.005. [Epub ahead of print]

Nachlinger, R.J.; Kauschke, V.; Trinkaus, K.; El Khassawna, T.; Heiss, C.; Lips, K.S. Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model. J J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):354-365.

Ray, S.; Thormann, U.; Eichelroth, M.; Budak, M.; Biehl, C.; Rupp, M.; Sommer, U.; El Khassawna, T.; Alagboso, F.I.; Kampschulte, M.; Rohnke, M.; Henß, A.; Peppler, K.; Linke, V.; Quadbeck, P.; Voigt, A.; Stenger, F.; Karl, D.; Schnettler, R.; Heiss, C.; Lips, K.S.; Alt, V. Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. Biomaterials. 2018 Mar;157:1-16. doi: 10.1016/j.biomaterials.2017.11.049. Epub 2017 Dec 1.

Daghma, D.E.S.; Malhan, D.; Simon, P.; Stötzel, S.; Kern, S.; Hassan, F.; Lips, K.S.; Heiss, C.; El Khassawna, T. Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine. J Bone Miner Metab. 2017 Jun 6. doi: 10.1007/s00774-017-0844-5. [Epub ahead of print]

El Khassawna, T.; Daghma, D.E.S.; Stoetzel, S.; Ray, S.; Kern, S.; Malhan, D.; Alt, V.; Thormann, U.; Henß, A.; Rohnke, M.; Stengel, A.; Hassan, F.; Maenz, S.; Jandt, K.D.; Diefenbeck, M.; Schumacher, M.; Gelinsky, M.; Lips, K.S.; Heiss, C. Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals. Biomed Res Int. 2017;2017:2023853.

El Khassawna, T.; Merboth, F.; Malhan, D.; Böcker, W.; Daghma, D.E.S.; Stoetzel, S.; Kern, S.; Hassan, F.; Rosenbaum, D.; Langenstein, J.; Bauer, N.; Schlagenhauf, A.; Rösen-Wolff, A.; Schulze, F.; Rupp, M.; Hose, D.; Secklinger, A.; Ignatius, A.; Wilke, H.J.; Lips, K.S.; Heiss, C. Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis. Am J Pathol. 2017 Jun 12. pii: S0002-9440(17)30132-3.

Heiss, C.; Kern, S.; Malhan, D.; Böcker, W.; Engelhardt, M.; Daghma, D.E.S.; Stoetzel, S.; Schmitt, J.; Ivo, M.; Kauschke, V.; Lips, K.S.; Tushtev, K.; Rezwan, K.; El Khassawna, T. A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model. Med Sci Monit Basic Res. 2017 Oct 2;23:326-335.

Lykhmus, O.; Voytenko, L.P.; Lips, K.S.; Bergen, I.; Krasteva-Christ, G.; Vetter, D.E.; Kummer, W.; Skok, M. Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice. Front Cell Neurosci. 2017 Sept 12. doi: 10.3389/fncel.2017.00282.

Ray, S.; Khassawna, T.E.; Sommer, U.; Thormann, U.; Wijekoon, N.D.; Lips, K.S.; Heiss, C.; Alt, V. Differences in expression of Wnt antagonist Dkk1 in healthy versus pathological bone samples. J Microsc. 2017 Jan;265(1):111-120.

Alt, V.; Cheung, W.H.; Chow, S.K.; Thormann, U.; Cheung, E.N.; Lips, K.S.; Schnettler, R.; Leung, K.S. Bone formation and degradation behavior of nanocrystalline hydroxyapatite with or without collagen-type 1 in osteoporotic bone defects - an experimental study in osteoporotic goats. Injury. 2016 Jun;47 Suppl 2:S58-65.

Augat, P.; Robioneck, P.B.; Abdulazim, A.; Wipf, F.; Lips, K.S.; Alt, V.; Schnettler, R.; Heiss, C. Fixation performance of an ultrasonically fused, bioresorbable osteosynthesis implant: A biomechanical and biocompatibility study. J Biomed Mater Res B Appl Biomater. 2016; 104(1):170-9.

Beckmann, J.; Dittmann, N.; Schütz, I.; Klein, J.; Lips, K.S. Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis. Arthritis Res Ther. 2016 Jan 19;18:17.

Charyeva, O.; Dakischew, O.; Sommer, U.; Heiss, C.; Schnettler, R.; Lips, K.S. Biocompatibility of magnesium implants in primary human reaming debris-derived cells stem cells in vitro. J Orthop Traumatol. 2016; 17(1):63-73.

Kampschulte, M.; Krombach, G.A.; Richards, D.C.; Sender, J.; Lips, K.S.; Thormann, U.; El Khassawna, T.; Ray, S.; Alt, V.; Langheinrich, A.C. Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.  Microvasc Res. 2016 May;105:7-14.

Mohamed, W.; Domann, E.; Chakraborty, T.; Mannala, G.; Lips, K.S.; Heiss, C.; Schnettler, R.; Alt, V. TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress. BMC Microbiology. 2016, 16(1):230.

Ray, S.; Thormann, U.; Sommer, U.; Khassawna, T.E.; Hundgeburth, M.; Henß, A.; Rohnke, M.; Lips, K.S.; Heiss, C.; Heinemann, S.; Hanke, T.; Dürselen, L.; Schnettler, R.; Alt, V. Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats. Injury. 2016 Jan;47 Suppl 1:S52-61.

Vehlow, D.; Schmidt, R.; Gebert, A.; Siebert, M.; Lips, K.S.; Müller, M. Polyelectrolyte Complex Based Interfacial Drug Delivery System with Controlled Loading and Improved Release Performance for Bone Therapeutics. Nanomaterials. 2016; 6(3), 53.

Ternes, S.; Trinkaus, K.; Bergen, I.; Knaack, S.; Gelinsky, M.; Kilian, O.; Heiss, C.; Lips, K.S. Impact of acetylcholine and nicotine on human osteoclastogenesis in vitro. Int Immunopharmacol. 2015 Nov;29(1):215-21.

Nassenstein, C.; Wiegand, S.; Lips, K.S.; Li, G.; Klein, J.; Kummer, W. Cholinergic activation of the murine trachealis muscle via non-vesicular acetylcholine release involving low-affinity choline transporters. Int Immunopharmacol. 2015 Nov;29(1):173-80.

Kauschke, V.; Kneffel, M.; Floel, W.; Hartmann, S.; Kampschulte, M.; Durselen, L.; Ignatius, A.; Schnettler, R.; Heiss, C.; Lips, K.S. Bone status of acetylcholinesterase-knockout mice. Int Immunopharmacol. 2015 Nov;29(1):222-30.

Charyeva, O.; Thormann, U.; Lips, K.S.; Heimann, L.; Sommer, U.; Szalay, G.; Alt, V.; Hort, N.; Schnettler, R.; Rauschmann, M.; Schmidt, S. Histological Comparison of New Biodegradable Magnesium-Based Implants for Maxillofacial Applications. Journal of maxillofacial and oral surgery. 2015a Sep;14(3):637-645.

Charyeva, O.; Feyerabend, F,; Willumeit, R.; Zukowski, D.; Gasqueres, C.; Szakacs, G.; Ahmad Agha, N.; Hort, N.; Gensch, F.; Cecchinato, F.; Jimbo, R.; Wennerberg, A.; Lips, K.S. In vitro resorption of magensium materials and ist effect on surface and surrounding environment. MOJ Toxicol. 2015;1(1):00004. DOI: 10.15406/mojt.2015.02.00004.

Zablotni, A.; Dakischew, O.; Trinkaus, K.; Hartmann, S.; Szalay, G.; Heiss, C.; Lips, K.S. Regulation of acetylcholine receptors during differentiation of bone mesenchymal stem cells harvested from human reaming debris. Int Immunopharmacol. 2015 Nov;29(1):119-26.

El Khassawna, T.; Bocker, W.; Brodsky, K.; Weisweiler, D.; Govindarajan, P.; Kampschulte, M.; Thormann, U.; Henss, A.; Rohnke, M.; Bauer, N.; Muller, R.; Deutsch, A.; Ignatius, A.; Durselen, L.; Langheinrich, A.; Lips, K.S.; Schnettler, R.; Heiss, C. Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol. 2015 Nov;144(5):491-507.

Beckmann, J.; Schubert, J.; Morhenn, H.G.; Grau, V.; Schnettler, R.; Lips, K.S. Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell Tissue Res. 2015 Feb;359(2):465-77.

Haupt, M.; Kauschke, V.; Sender, J.; Kampschulte, M.; Kovtun, A.; Durselen, L.; Heiss, C.; Lips, K.S. Bone status of adult female butyrylcholinesterase gene-deficient mice. Int Immunopharmacol. 2015 Nov;29(1):208-14.

Lips, K.S.; Kneffel, M.; Willscheid, F.; Mathies, F.M.; Kampschulte, M.; Hartmann, S.; Panzer, I.; Durselen, L.; Heiss, C.; Kauschke, V. Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice. Int Immunopharmacol. 2015 Nov;29(1):201-7.

Lautenschläger, S.; Striegler, C.; Dakischew, O.; Schütz, I.; Szalay, G.; Schnettler, R.; Heiß, C.; Appelhans, D.; Lips, K.S. Effects of dendritic core-shell glycoarchitectures on primary mesenchymal stem cells and osteoblasts obtained from different human donors. J Nanobiotechnology. 2015 Oct 8;13(1):65.

Thormann, U.; Alt, V.; Heimann, L.; Gasquere, C.; Heiss, C.; Szalay, G.; Franke, J.; Schnettler, R.; Lips, K.S. The biocompatibility of degradable magnesium interference screws: an experimental study with sheep. BioMed research international. 2015;2015:943603.

Pauksch, L.; Franke, J.; Schnettler, R.; Lips, K.S. Synergistic toxicity of gentamicin- and nanosilver-doped polymethylmethacrylate bone cement on primary human osteoclasts. Cells, tissues, organs. 2014a;199(5-6):384-392.

Lips, K.S.; Yanko, O.; Kneffel, M.; Panzer, I.; Kauschke, V.; Madzharova, M.; Henss, A.; Schmitz, P.; Rohnke, M.; Bauerle, T.; Liu, Y.; Kampschulte, M.; Langheinrich, A.C.; Durselen, L.; Ignatius, A.; Heiss, C.; Schnettler, R.; Kilian, O. Small changes in bone structure of female alpha7 nicotinic acetylcholine receptor knockout mice. BMC musculoskeletal disorders. 2015b;16:5.

Lorenzetti, M.; Dakischew, O.; Trinkaus, K.; Lips, K.S.; Schnettler, R.; Kobe, S.; Novak, S. Enhanced osteogenesis on titanium implants by UVB photofunctionalization of hydrothermally grown TiO(2) coatings. Journal of biomaterials applications. 2015 Jul;30(1):71-84.

Pauksch, L.; Hartmann, S.; Szalay, G.; Alt, V.; Lips, K.S. In vitro assessment of nanosilver-functionalized PMMA bone cement on primary human mesenchymal stem cells and osteoblasts. PloS one. 2014b;9(12):e114740.

Beckmann, J.; Schubert, J.; Morhenn, H.G.; Grau, V.; Schnettler, R.; Lips, K.S. Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell and tissue research. 2015 Feb;359(2):465-477.

Mohamed, W.; Sommer, U.; Sethi, S.; Domann, E.; Thormann, U.; Schutz, I.; Lips, K.S.; Chakraborty, T.; Schnettler, R.; Alt, V. Intracellular proliferation of S. aureus in osteoblasts and effects of rifampicin and gentamicin on S. aureus intracellular proliferation and survival. European cells & materials. 2014;28:258-268.

Kilian, O.; Hartmann, S.; Dongowski, N.; Karnati, S.; Baumgart-Vogt, E.; Hartel, F.V.; Noll, T.; Schnettler, R.; Lips, K.S. BDNF and its TrkB receptor in human fracture healing. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2014 Sep;196(5):286-295.

Alt, V.; Kirchhof, K.; Seim, F.; Hrubesch, I.; Lips, K.S.; Mannel, H.; Domann, E.; Schnettler, R. Rifampicin-fosfomycin coating for cementless endoprostheses: antimicrobial effects against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). Acta biomaterialia. 2014 Oct;10(10):4518-4524.

Lips, K.S.; Kauschke, V.; Hartmann, S.; Thormann, U.; Ray, S.; Schumacher, M.; Gelinsky, M.; Heinemann, S.; Hanke, T.; Kautz, A.R.; Schnabelrauch, M.; Szalay, G.; Heiss, C.; Schnettler, R.; Alt, V.; Kilian, O. Cholinergic nerve fibers in bone defects of a rat osteoporosis model and their regulation by implantation of bone substitution materials. Journal of musculoskeletal & neuronal interactions. 2014 Jun;14(2):173-188.

Kauschke, V.; Lips, K.S.; Heiss, C.; Schnettler, R. Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis. Medical science monitor : international medical journal of experimental and clinical research. 2014;20:869-874.

Khalil, F.; Franzmann, E.; Ramcke, J.; Dakischew, O.; Lips, K.S.; Reinhardt, A.; Heisig, P.; Maison, W. Biomimetic PEG-catecholates for stabile antifouling coatings on metal surfaces: applications on TiO2 and stainless steel. Colloids and surfaces B, Biointerfaces. 2014 May 1;117:185-192.

Fehrendt, H.; Linn, T.; Hartmann, S.; Szalay, G.; Heiss, C.; Schnettler, R.; Lips, K.S. Negative influence of a long-term high-fat diet on murine bone architecture. International journal of endocrinology. 2014;2014:318924.

Thormann, U.; El Khawassna, T.; Ray, S.; Duerselen, L.; Kampschulte, M.; Lips, K.; von Dewitz, H.; Heinemann, S.; Heiss, C.; Szalay, G.; Langheinrich, A.C.; Ignatius, A.; Schnettler, R.; Alt, V. Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats. Injury. 2014 Mar;45(3):487-493.

Govindarajan, P.; Bocker, W.; El Khassawna, T.; Kampschulte, M.; Schlewitz, G.; Huerter, B.; Sommer, U.; Durselen, L.; Ignatius, A.; Bauer, N.; Szalay, G.; Wenisch, S.; Lips, K.S.; Schnettler, R.; Langheinrich, A.; Heiss, C. Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet. The American journal of pathology. 2014 Mar;184(3):765-777.

Pauksch, L.; Hartmann, S.; Rohnke, M.; Szalay, G.; Alt, V.; Schnettler, R.; Lips, K.S. Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts. Acta biomaterialia. 2014c Jan;10(1):439-449.

El Khassawna, T.; Bocker, W.; Govindarajan, P.; Schliefke, N.; Hurter, B.; Kampschulte, M.; Schlewitz, G.; Alt, V.; Lips, K.S.; Faulenbach, M.; Mollmann, H.; Zahner, D.; Durselen, L.; Ignatius, A.; Bauer, N.; Wenisch, S.; Langheinrich, A.C.; Schnettler, R.; Heiss, C. Effects of multi-deficiencies-diet on bone parameters of peripheral bone in ovariectomized mature rat. PloS one. 2013;8(8):e71665.

Govindarajan, P.; Schlewitz, G.; Schliefke, N.; Weisweiler, D.; Alt, V.; Thormann, U.; Lips, K.S.; Wenisch, S.; Langheinrich, A.C.; Zahner, D.; Hemdan, N.Y.; Bocker, W.; Schnettler, R.; Heiss, C. Implications of combined ovariectomy/multi-deficiency diet on rat bone with age-related variation in bone parameters and bone loss at multiple skeletal sites by DEXA. Medical science monitor basic research. 2013;19:76-86.

Gruner, D.; Lips, K.S.; Heiss, C.; Schnettler, R.; Kollmann, T.; Simon, P.; Kniep, R. Irregular shaped, assumably semi-crystalline calciumphosphate platelet deposition at the mineralization front of rabbit femur osteotomy: a HR-TEM study. Scanning. 2013 May-Jun;35(3):169-182.

Lips, K.S.; Kauschke, V.; Hartmann, S.; Thormann, U.; Ray, S.; Kampschulte, M.; Langheinrich, A.; Schumacher, M.; Gelinsky, M.; Heinemann, S.; Hanke, T.; Kautz, A.R.; Schnabelrauch, M.; Schnettler, R.; Heiss, C.; Alt, V.; Kilian, O. Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures. PloS one. 2013;8(10):e77259.

Nandigama, R.; Ibanez-Tallon, I.; Lips, K.S.; Schwantes, U.; Kummer, W.; Bschleipfer, T. Expression of nicotinic acetylcholine receptor subunit mRNA in mouse bladder afferent neurons. Neuroscience. 2013 Jan 15;229:27-35.

Alt, V.; Thormann, U.; Ray, S.; Zahner, D.; Durselen, L.; Lips, K.; El Khassawna, T.; Heiss, C.; Riedrich, A.; Schlewitz, G.; Ignatius, A.; Kampschulte, M.; von Dewitz, H.; Heinemann, S.; Schnettler, R.; Langheinrich, A. A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures. Acta biomaterialia. 2013 Jun;9(6):7035-7042.

Schleicher, I.; Lips, K.S.; Sommer, U.; Schappat, I.; Martin, A.P.; Szalay, G.; Hartmann, S.; Schnettler, R. Biphasic scaffolds for repair of deep osteochondral defects in a sheep model. The Journal of surgical research. 2013a Jul;183(1):184-192.

Schleicher, I.; Lips, K.S.; Sommer, U.; Schappat, I.; Martin, A.P.; Szalay, G.; Schnettler, R. Allogenous bone with collagen for repair of deep osteochondral defects. The Journal of surgical research. 2013b Dec;185(2):667-675.

Schlewitz, G.; Govindarajan, P.; Schliefke, N.; Alt, V.; Bocker, W.; Elkhassawna, T.; Thormann, U.; Lips, K.S.; Hemdan, N.Y.; Zahner, D.; Schnettler, R.; Heiss, C. [Ovariectomy and calcium/vitamin D2/D3 deficient diet as a model of osteoporosis in the spine of Sprague-Dawley rats]. Zeitschrift fur Orthopadie und Unfallchirurgie. 2013 Feb;151(1):14-19.

Thormann, U.; Ray, S.; Sommer, U.; Elkhassawna, T.; Rehling, T.; Hundgeburth, M.; Henss, A.; Rohnke, M.; Janek, J.; Lips, K.S.; Heiss, C.; Schlewitz, G.; Szalay, G.; Schumacher, M.; Gelinsky, M.; Schnettler, R.; Alt, V. Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats. Biomaterials. 2013 Nov;34(34):8589-8598.

Bschleipfer, T.; Weidner, W.; Kummer, W.; Lips, K.S. Does bladder outlet obstruction alter the non-neuronal cholinergic system of the human urothelium? Life sciences. 2012 Nov 27;91(21-22):1082-1086.

Heiss, C.; Govindarajan, P.; Schlewitz, G.; Hemdan, N.Y.; Schliefke, N.; Alt, V.; Thormann, U.; Lips, K.S.; Wenisch, S.; Langheinrich, A.C.; Zahner, D.; Schnettler, R. Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA. Medical science monitor : international medical journal of experimental and clinical research. 2012 Jun;18(6):BR199-207.

Hollenhorst, M.I.; Lips, K.S.; Kummer, W.; Fronius, M. Nicotine-induced activation of soluble adenylyl cyclase participates in ion transport regulation in mouse tracheal epithelium. Life sciences. 2012a Nov 27;91(21-22):1009-1012.

Kliemann, K.; Kneffel, M.; Bergen, I.; Kampschulte, M.; Langheinrich, A.C.; Durselen, L.; Ignatius, A.; Kilian, O.; Schnettler, R.; Lips, K.S. Quantitative analyses of bone composition in acetylcholine receptor M3R and alpha7 knockout mice. Life sciences. 2012 Nov 27;91(21-22):997-1002.

Schubert, J.; Beckmann, J.; Hartmann, S.; Morhenn, H.G.; Szalay, G.; Heiss, C.; Schnettler, R.; Lips, K.S. Expression of the non-neuronal cholinergic system in human knee synovial tissue from patients with rheumatoid arthritis and osteoarthritis. Life sciences. 2012 Nov 27;91(21-22):1048-1052.

Wolff, M.; Noreikat, K.; Ibanez-Tallon, I.; Lips, K.S.; Kolle, S.; Kummer, W. Cholinergic receptors in the murine oviduct: inventory and coupling to intracellular calcium concentration. Life sciences. 2012 Nov 27;91(21-22):1003-1008.

Hollenhorst, M.I.; Lips, K.S.; Weitz, A.; Krasteva, G.; Kummer, W.; Fronius, M. Evidence for functional atypical nicotinic receptors that activate K+-dependent Cl- secretion in mouse tracheal epithelium. American journal of respiratory cell and molecular biology. 2012b Jan;46(1):106-114.

Hollenhorst, M.I.; Lips, K.S.; Wolff, M.; Wess, J.; Gerbig, S.; Takats, Z.; Kummer, W.; Fronius, M. Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca(2)(+)-dependent Cl(-) and K(+) channels. British journal of pharmacology. 2012c Jun;166(4):1388-1402.

Paddenberg, R.; Tiefenbach, M.; Faulhammer, P.; Goldenberg, A.; Gries, B.; Pfeil, U.; Lips, K.S.; Piruat, J.I.; Lopez-Barneo, J.; Schermuly, R.T.; Weissmann, N.; Kummer, W. Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries. Cardiovascular research. 2012 Mar 15;93(4):702-710.

Alt, V.; Kogelmaier, D.V.; Lips, K.S.; Witt, V.; Pacholke, S.; Heiss, C.; Kampschulte, M.; Heinemann, S.; Hanke, T.; Thormann, U.; Schnettler, R.; Langheinrich, A.C. Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CT. Acta biomaterialia. 2011a Oct;7(10):3773-3779.

Alt, V.; Lips, K.S.; Henkenbehrens, C.; Muhrer, D.; Oliveira Cavalcanti, M.C.; Sommer, U.; Thormann, U.; Szalay, G.; Heiss, C.; Pavlidis, T.; Domann, E.; Schnettler, R. A new animal model for implant-related infected non-unions after intramedullary fixation of the tibia in rats with fluorescent in situ hybridization of bacteria in bone infection. Bone. 2011b May 1;48(5):1146-1153.

Kraus, R.; Peters, F.; Geck, A.; Lips, K.S.; Obert, M.; Roder, C.; Schnabelrauch, M.; Schnettler, R.; Heiss, C. [Adhesive strength of a beta-tricalcium phosphate-enriched bone adhesive]. Zeitschrift fur Orthopadie und Unfallchirurgie. 2011 Jun;149(3):271-278.

Offer, L.; Veigel, B.; Pavlidis, T.; Heiss, C.; Gelinsky, M.; Reinstorf, A.; Wenisch, S.; Lips, K.S.; Schnettler, R. Phosphoserine-modified calcium phosphate cements: bioresorption and substitution. Journal of tissue engineering and regenerative medicine. 2011 Jan;5(1):11-19.

Schirmer, S.U.; Eckhardt, I.; Lau, H.; Klein, J.; DeGraaf, Y.C.; Lips, K.S.; Pineau, C.; Gibbins, I.L.; Kummer, W.; Meinhardt, A.; Haberberger, R.V. The cholinergic system in rat testis is of non-neuronal origin. Reproduction (Cambridge, England). 2011 Jul;142(1):157-166.

Heiss, C.; Schettler, N.; Wenisch, S.; Cords, S.; Schilke, F.; Lips, K.S.; Alt, V.; Schnettler, R. Bond strength of an alkylene bis(dilactoyl)-methacrylate bone adhesive: a biomechanical evaluation in sheep. Journal of biomaterials science Polymer edition. 2010;21(10):1345-1358.

Mikulski, Z.; Hartmann, P.; Jositsch, G.; Zaslona, Z.; Lips, K.S.; Pfeil, U.; Kurzen, H.; Lohmeyer, J.; Clauss, W.G.; Grau, V.; Fronius, M.; Kummer, W. Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respiratory research. 2010;11:133.

En-Nosse, M.; Hartmann, S.; Trinkaus, K.; Alt, V.; Stigler, B.; Heiss, C.; Kilian, O.; Schnettler, R.; Lips, K.S. Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis. Cell and tissue research. 2009 Nov;338(2):203-215.

Hecker, A.; Mikulski, Z.; Lips, K.S.; Pfeil, U.; Zakrzewicz, A.; Wilker, S.; Hartmann, P.; Padberg, W.; Wessler, I.; Kummer, W.; Grau, V. Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts. Journal of leukocyte biology. 2009 Jul;86(1):13-22.

Klein, M.K.; Haberberger, R.V.; Hartmann, P.; Faulhammer, P.; Lips, K.S.; Krain, B.; Wess, J.; Kummer, W.; Konig, P. Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. The European respiratory journal. 2009 May;33(5):1113-1121.

Shelukhina, I.V.; Kryukova, E.V.; Lips, K.S.; Tsetlin, V.I.; Kummer, W. Presence of alpha7 nicotinic acetylcholine receptors on dorsal root ganglion neurons proved using knockout mice and selective alpha-neurotoxins in histochemistry. Journal of neurochemistry. 2009 May;109(4):1087-1095.

Biallas, S.; Wilker, S.; Lips, K.S.; Kummer, W.; Grando, S.A.; Padberg, W.; Grau, V. Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts. Life sciences. 2007 May 30;80(24-25):2286-2289.

Bschleipfer, T.; Schukowski, K.; Weidner, W.; Grando, S.A.; Schwantes, U.; Kummer, W.; Lips, K.S. Expression and distribution of cholinergic receptors in the human urothelium. Life sciences. 2007 May 30;80(24-25):2303-2307.

Grau, V.; Wilker, S.; Lips, K.S.; Hartmann, P.; Rose, F.; Padberg, W.; Fehrenbach, H.; Wessler, I.; Kummer, W. Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine production. The international journal of biochemistry & cell biology. 2007a;39(10):1955-1963.

Zarghooni, S.; Wunsch, J.; Bodenbenner, M.; Bruggmann, D.; Grando, S.A.; Schwantes, U.; Wess, J.; Kummer, W.; Lips, K.S. Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life sciences. 2007 May 30;80(24-25):2308-2313.

Grau, V.; Wilker, S.; Hartmann, P.; Lips, K.S.; Grando, S.A.; Padberg, W.; Fehrenbach, H.; Kummer, W. Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10. Life sciences. 2007b May 30;80(24-25):2290-2293.

Krasteva, G.; Pfeil, U.; Filip, A.M.; Lips, K.S.; Kummer, W.; Konig, P. Caveolin-3 and eNOS colocalize and interact in ciliated airway epithelial cells in the rat. The international journal of biochemistry & cell biology. 2007;39(3):615-625.

Lips, K.S.; Luhrmann, A.; Tschernig, T.; Stoeger, T.; Alessandrini, F.; Grau, V.; Haberberger, R.V.; Koepsell, H.; Pabst, R.; Kummer, W. Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Life sciences. 2007a May 30;80(24-25):2263-2269.

Lips, K.S.; Wunsch, J.; Zarghooni, S.; Bschleipfer, T.; Schukowski, K.; Weidner, W.; Wessler, I.; Schwantes, U.; Koepsell, H.; Kummer, W. Acetylcholine and molecular components of its synthesis and release machinery in the urothelium. European urology. 2007b Apr;51(4):1042-1053.

Galvis, G.; Lips, K.S.; Kummer, W. Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. Journal of molecular neuroscience : MN. 2006;30(1-2):107-108.

Hecker, A.; Lips, K.S.; Pfeil, U.; Kummer, W.; Padberg, W.; Grau, V. Peripheral choline acetyltransferase is expressed by monocytes and upregulated during renal allograft rejection in rats. Journal of molecular neuroscience : MN. 2006;30(1-2):23-24.

Kummer, W.; Wiegand, S.; Akinci, S.; Schinkel, A.H.; Wess, J.; Koepsell, H.; Haberberger, R.V.; Lips, K.S. Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. Journal of molecular neuroscience : MN. 2006a;30(1-2):67-68.

Kummer, W.; Wiegand, S.; Akinci, S.; Wessler, I.; Schinkel, A.H.; Wess, J.; Koepsell, H.; Haberberger, R.V.; Lips, K.S. Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respiratory research. 2006b;7:65.

Lips, K.S.; Konig, P.; Schatzle, K.; Pfeil, U.; Krasteva, G.; Spies, M.; Haberberger, R.V.; Grando, S.A.; Kummer, W. Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neurons. Journal of molecular neuroscience : MN. 2006;30(1-2):15-16.

Spies, M.; Lips, K.S.; Kurzen, H.; Kummer, W.; Haberberger, R.V. Nicotinic acetylcholine receptors containing subunits alpha3 and alpha5 in rat nociceptive dorsal root ganglion neurons. Journal of molecular neuroscience : MN. 2006;30(1-2):55-56.

Berse, B.; Szczecinska, W.; Lopez-Coviella, I.; Madziar, B.; Zemelko, V.; Kaminski, R.; Kozar, K.; Lips, K.S.; Pfeil, U.; Blusztajn, J.K. Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro. Brain research Developmental brain research. 2005 Jun 30;157(2):132-140.

Dvorakova, M.; Lips, K.S.; Bruggmann, D.; Slavikova, J.; Kuncova, J.; Kummer, W. Developmental changes in the expression of nicotinic acetylcholine receptor alpha-subunits in the rat heart. Cell and tissue research. 2005 Feb;319(2):201-209.

Lips, K.S.; Bruggmann, D.; Pfeil, U.; Vollerthun, R.; Grando, S.A.; Kummer, W. Nicotinic acetylcholine receptors in rat and human placenta. Placenta. 2005a Nov;26(10):735-746.

Lips, K.S.; Volk, C.; Schmitt, B.M.; Pfeil, U.; Arndt, P.; Miska, D.; Ermert, L.; Kummer, W.; Koepsell, H. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. American journal of respiratory cell and molecular biology. 2005b Jul;33(1):79-88.

Muller, J.; Lips, K.S.; Metzner, L.; Neubert, R.H.; Koepsell, H.; Brandsch, M. Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochemical pharmacology. 2005 Dec 5;70(12):1851-1860.

Obreja, O.; Biasio, W.; Andratsch, M.; Lips, K.S.; Rathee, P.K.; Ludwig, A.; Rose-John, S.; Kress, M. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain : a journal of neurology. 2005 Jul;128(Pt 7):1634-1641.

Haberberger, R.V.; Bernardini, N.; Kress, M.; Hartmann, P.; Lips, K.S.; Kummer, W. Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat. Autonomic neuroscience : basic & clinical. 2004 Jun 30;113(1-2):32-42.

Papadopolou, S.; Hartmann, P.; Lips, K.S.; Kummer, W.; Haberberger, R.V. Nicotinic receptor mediated stimulation of NO-generation in neurons of rat thoracic dorsal root ganglia. Neuroscience letters. 2004 May 6;361(1-3):32-35.

Pfeil, U.; Vollerthun, R.; Kummer, W.; Lips, K.S. Expression of the cholinergic gene locus in the rat placenta. Histochemistry and cell biology. 2004 Aug;122(2):121-130.

Lips, K.S.; Pfeil, U.; Reiners, K.; Rimasch, C.; Kuchelmeister, K.; Braun-Dullaeus, R.C.; Haberberger, R.V.; Schmidt, R.; Kummer, W. Expression of the high-affinity choline transporter CHT1 in rat and human arteries. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2003 Dec;51(12):1645-1654.

Bruggmann, D.; Lips, K.S.; Pfeil, U.; Haberberger, R.V.; Kummer, W. Rat arteries contain multiple nicotinic acetylcholine receptor alpha-subunits. Life sciences. 2003 Mar 28;72(18-19):2095-2099.

Distler, C.; Rathee, P.K.; Lips, K.S.; Obreja, O.; Neuhuber, W.; Kress, M. Fast Ca2+-induced potentiation of heat-activated ionic currents requires cAMP/PKA signaling and functional AKAP anchoring. Journal of neurophysiology. 2003 May;89(5):2499-2505.

Haberberger, R.V.; Henrich, M.; Lips, K.S.; Kummer, W. Nicotinic receptor alpha 7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neurons. Histochemistry and cell biology. 2003 Sep;120(3):173-181.

Pfeil, U.; Haberberger, R.V.; Lips, K.S.; Eberling, L.; Grau, V.; Kummer, W. Expression of the high-affinity choline transporter CHT1 in epithelia. Life sciences. 2003a Mar 28;72(18-19):2087-2090.

Pfeil, U.; Lips, K.S.; Eberling, L.; Grau, V.; Haberberger, R.V.; Kummer, W. Expression of the high-affinity choline transporter, CHT1, in the rat trachea. American journal of respiratory cell and molecular biology. 2003b Apr;28(4):473-477.

Arredondo, J.; Nguyen, V.T.; Chernyavsky, A.I.; Bercovich, D.; Orr-Urtreger, A.; Kummer, W.; Lips, K.; Vetter, D.E.; Grando, S.A. Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. The Journal of cell biology. 2002 Oct 28;159(2):325-336.

Bruggmann, D.; Lips, K.S.; Pfeil, U.; Haberberger, R.V.; Kummer, W. Multiple nicotinic acetylcholine receptor alpha-subunits are expressed in the arterial system of the rat. Histochemistry and cell biology. 2002 Dec;118(6):441-447.

Haberberger, R.V.; Pfeil, U.; Lips, K.S.; Kummer, W. Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. The Journal of investigative dermatology. 2002 Oct;119(4):943-948.

Lips, K.S.; Pfeil, U.; Haberberger, R.V.; Kummer, W. Localisation of the high-affinity choline transporter-1 in the rat skeletal motor unit. Cell and tissue research. 2002a Mar;307(3):275-280.

Lips, K.S.; Pfeil, U.; Kummer, W. Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons. Neuroscience. 2002b;115(1):1-5.

Obreja, O.; Rathee, P.K.; Lips, K.S.; Distler, C.; Kress, M. IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 Oct;16(12):1497-1503.

Lips, K.S.; Kaltner, H.; Reuter, G.; Stierstorfer, B.; Sinowatz, F.; Gabius, H.J. Correspondence of gradual developmental increases of expression of galectin-reactive glycoconjugates with alterations of the total contents of the two differentially regulated galectins in chicken intestine and liver as indication for overlapping functions. Histology and histopathology. 1999 Jul;14(3):743-760.

Kaltner, H.; Lips, K.S.; Reuter, G.; Lippert, S.; Sinowatz, F.; Gabius, H.J. Quantitation and histochemical localization of galectin-1 and galectin-1-reactive glycoconjugates in fetal development of bovine organs. Histology and histopathology. 1997 Oct;12(4):945-960.

Kortje, K.H.; Aich, B.; Lips, K.; Rahmann, H. Cellular substructures in the optic tectum of Antarctic and temperate fish. J Zool. 1996 Feb;238:333-350.

Stichel, C.C.; Lips, K.; Wunderlich, G.; Muller, H.W. Reconstruction of transected postcommissural fornix in adult rat by Schwann cell suspension grafts. Experimental neurology. 1996 Jul;140(1):21-36.

Lips, K.; Stichel, C.C.; Muller, H.W. Restricted appearance of tenascin and chondroitin sulphate proteoglycans after transection and sprouting of adult rat postcommissural fornix. Journal of neurocytology. 1995 Jun;24(6):449-464.

Übersichtsarbeiten:

Beckmann, J.; Lips, K.S. The non-neuronal cholinergic system in health and disease. Pharmacology. 2013;92(5-6):286-302.

Kummer, W.; Lips, K.S.; Pfeil, U. The epithelial cholinergic system of the airways. Histochemistry and cell biology. 2008 Aug;130(2):219-234.