C12 boost RT; sinu-nasal cancer
This trial examines the effect of a carbon ion boost in the treatment of patients with unresected or incompletely resected nasal or paranasal sinus carcinomas . It is a prospective non-randomized phase II trial evaluating the acute effects on the mucosa (rate of mucositis III°) as primary endpoint. Patients start with 8 x 3 GyE carbon ion boost, followed by 25 x 2 Gy photon IMRT. In addition, proteomic and genomic examinations were performed out of the peripheral blood of the treated patients.